698389-81-0Relevant academic research and scientific papers
Facile synthesis of 2-alkynyl buta-1,3-dienes via Sonogashira cross-coupling methodology
Shao, Li-Xiong,Shi, Min
, p. 8635 - 8637 (2005)
2-Alkynyl buta-1,3-dienes 4 can be synthesized in moderate to high yields by the reactions of the corresponding diiodides 1 derived from methylenecyclopropanes with substituted alkynes 2 via Sonogashira cross-coupling in the catalysis of Pd(PPh3/sub
Facile synthesis of multisubstituted buta-1,3-dienes via Suzuki-Miyaura and Kumada cross-coupling strategy of 2,4-diiodo-buta-1-enes with arylboronic acids and Grignard reagents
Shao, Li-Xiong,Shi, Min
, p. 1828 - 1831 (2007/10/03)
One-pot Suzuki-Miyaura-type and Kumada-type cross-coupling reactions of 2,4-diiodo-buta-l-enes with arylboronic acids and alkyl/aryl magnesium bromides were carried out in the presence of accessibly simple catalysts under mild conditions. As a result, some 1,1,2-trisubstituted buta-1,3-dienes were obtained including the Tamoxifen-type, which have potential adjuvant therapy in women who have suffered from breast cancer and cyclooxygenase-2-type (COX-2-type) inhibitors, some of which have been proved to elicit efficient anti-inflammatory analgesic activities and less adverse gastrointestinal side effects and to be very useful in the prophylactic treatment of a wide variety of cancers and neurodegenerative disorders. The Royal Society of Chemistry 2005.
Facile synthesis of cross-conjugated gem-disubstituted trienes via palladium-catalyzed cross-coupling protocol of 1,1-disubstituted 2,4-diiodo-but-1-ene with alkenes
Shi, Min,Shao, Li-Xiong
, p. 807 - 810 (2007/10/03)
Cross-conjugated coupling products described in the title are obtained in moderate to high yields by the reactions of the corresponding 1,1-disubstituted 2,4-diiodo-but-1-enes, which are derived from the ring-opening reaction of methylenecyclopropanes with iodine, with substituted alkenes in the presence of palladium(II) catalyst under simple Heck-type reaction conditions.
