698396-93-9

Usage

Pyridine ring

a six-membered aromatic ring with one nitrogen atom

Indole ring

a bicyclic structure consisting of a six-membered aromatic ring fused to a five-membered nitrogen-containing ring

Carboximidamide functional group

a group consisting of a carbonyl group (C=O) and an amide group (-NH2) attached to the same carbon atom

Methyl group

a carbon atom bonded to three hydrogen atoms

Nitrophenyl group

a group consisting of a six-membered aromatic ring with a nitro group (-NO2) attached

Hydroxy oxo functional group

a group consisting of a carbonyl group (C=O) and a hydroxy group (-OH) attached to the same carbon atom
Both compounds have potential applications in research and pharmaceuticals due to their unique structures and biological activities. They may be used as drug candidates for various diseases, as well as in biochemical research to understand their roles in pathways and processes. Their chemical structures may also be useful for designing and synthesizing new compounds with desired properties and activities.

Upstream product

• 352548-47-1 5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile 
• 304465-35-8 1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile 
• 167954-14-5 3-[N-(4-nitrophenyl)amino]-2-formylindole 
• 167954-19-0 3-[N-(4-nitrophenyl)amino]indole 
• 100-01-6 4-nitro-aniline 
• 33025-60-4 1-(3-hydroxy-1H-indol-1-yl)ethanone 

Downstream Products

• 698396-95-1 5-methyl-1-(4-nitrophenyl)-3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-1,5-dihydro-pyrido[3,2-b]indol-2-one 
• 698396-87-1 C₂₀H₁₃N₅O₅ 
• 698396-96-2 C₂₀H₁₃N₅O₄S 

Relevant academic research and scientific papers

COMBINATIONS OF SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO- [3,2-B] INDOL-2-ONES AND OTHER HIV INHIBITORS

The present invention concerns combinations comprising a compound of formula (I); the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters or metabolites thereof, wherein n is 1, 2 or 3; R1 is H, CN, halo, aminoC(=O), C(=O)OH, C1-4alkyloxyC(=O), C1-4 alkylC(=O), mono- or di(C1-4alkyl)aminoC(=O), arylaminoC(=O), N-(aryl)-N-(C1-4 alkyl)aminoC(=O), methanimidamidyl,N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; R2 is H, C1-10alkyl, C2-10alkenyl, C3-7cycloalkyl, wherein said C1-10alkyl, C2-10alkenyl and C3-7 cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxyC(=O), aminoC(=O), C1-4alkyloxyC(=O), mono- or di(C1-4alkyl)aminoC(=O), C1-4alkylC(=O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl,N-hydroxy-methanimidamidyl or Het1; and another HIV inhibitor. The invention also concerns products comprising a compound of formula (I) and another HIV inhibitor, as a combined preparation for simultaneous, separate or sequential use in treatment of retroviral infections such as HIV infection, in particular, in the treatment of infections with multi-drug resistant retroviruses.

SUBSTITUTED INDOLEPYRIDINIUM AS ANTI-INFECTIVE COMPOUNDS

The present invention concerns the compounds of formula (I) their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1is H, CN, halo, aminoC(=O), C(=O)OH, C1-4alkyloxyC(=O), C1-4alkylC(=O), mono- or di(C1-4alkyl)aminoC(=O), arylaminoC(=O), N-(aryl)-N-(C1-4alkyl)aminoC(=O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; R2 is H, C1-10alkyl, C2-10alkenyl, C3-7cycloalkyl, wherein said C1-10alkyl, C2-10alkenyl and C3-7cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxyC(=O), aminoC(=O), C1-4alkyloxyC(=O), mono- or di(C1-4alkyl)aminoC(=O), C1-4alkylC(=O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1; for use as a medicine. The invention further relates to a novel subgroup of the compounds of formula (I), and to compositions comprising compounds of formula (I)