69888-33-1

Basic information

• Product Name: 7-benzyloxy-4-hydroxy-5-methoxycoumarin
• CAS NO: 69888-33-1
• Molecular Weight: 298.295
• Mol File: 69888-33-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-benzyloxy-4-hydroxy-5-methoxycoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 7-benzyloxy-4-hydroxy-5-methoxycoumarin(69888-33-1)
• EPA Substance Registry System: 7-benzyloxy-4-hydroxy-5-methoxycoumarin(69888-33-1)

Safety Data

• Hazardous Substances Data: 69888-33-1(Hazardous Substances Data)

Upstream product

• 39548-89-5 1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one 
• 105-58-8 Diethyl carbonate 
• 76609-41-1 ethyl 7-benzyloxy-4-hydroxy-5-methoxy-3-carboxylate 

Relevant articles and documents

Synthesis of 5-Allyloxy-7-hydroxycoumarin

5-Allyloxy-7-hydroxycoumarin (I) has been synthesised by an unambiguous method starting from 6-allyloxy-α-benzyloxy-2-hydroxyacetophenone (IIa), which on cyclisation with diethyl carbonate in the presence of sodium methoxide gives 5-allyloxy-7-benzyloxy-4-hydroxycoumarin (IIIa) along with ethyl 5-allyloxy-7-benzyloxy-4-hydroxycoumarin-3-carboxylate (IVa).Tosylation of IIIa followed by reductive detosylation with Zn-HCl affords I, identical with the natural sample.The formation of coumarin-3-carboxylates has also been observed in the case of 6-benzyloxy-2-hydroxy-4-methoxyacetophenone (IIc) and 4-benzyloxy-2-hydroxy-6-methoxyacetophenone (IId).