69888-91-1

Basic information

• Product Name: 3-(3-fluoro-4-hydroxyphenyl)propionic acid
• Synonyms: 3-(3-fluoro-4-hydroxyphenyl)propionic acid;3-Fluoro-4-hydroxybenzenepropionic acid;3-(3-fluoro-4-hydroxyphenyl)propanoic acid
• CAS NO: 69888-91-1
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.1643632
• EINECS: 274-187-4
• Mol File: 69888-91-1.mol

Chemical Properties

• Boiling Point: 329.3°C at 760 mmHg
• Flash Point: 152.9°C
• Appearance: /
• Density: 1.353g/cm³
• Vapor Pressure: 7.21E-05mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 3-(3-fluoro-4-hydroxyphenyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-fluoro-4-hydroxyphenyl)propionic acid(69888-91-1)
• EPA Substance Registry System: 3-(3-fluoro-4-hydroxyphenyl)propionic acid(69888-91-1)

Safety Data

• Hazardous Substances Data: 69888-91-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H9FO3/c10-7-5-6(1-3-8(7)11)2-4-9(12)13/h1,3,5,11H,2,4H2,(H,12,13)

Upstream product

• 2105-94-4 4-bromo-2-fluorophenol 
• 877064-69-2 methyl (E)-3-(3-fluoro-4-hydroxyphenyl)acrylate 
• 590417-24-6 3-(3-fluoro-4-hydroxyphenyl)propionic acid methyl ester 
• 69888-90-0 3-(3-fluoro-4-methoxyphenyl)propionic acid 

Downstream Products

• 917885-01-9 5-fluoro-6-hydroxyindan-1-one 

Relevant articles and documents

Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT1A receptor and the serotonin transporter

The structure-activity relationship (SAR) for three series of lactam-fused chroman derivatives possessing 3-amino substituents was evaluated. Many compounds exhibited affinities for both the 5-HT1A receptor and the 5-HT transporter. Compounds 45 and 53 demonstrated 5-HT1A antagonist activities in the in vitro cAMP turnover model.

TRICYCLIC COMPOUNDS USEFUL AS SEROTONIN INHIBITORS AND 5-HT1A AGONISTS AND ANTAGONISTS

3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT1A receptor (agonizing or antagonizing) in a patient. These compounds are further useful for inhibiting binding to a serotonin receptor. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.

Substituted phenylalkanoic acid derivatives and use thereof

A compound represented by the formula (I) or a salt thereof: wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the following formula: R1(CH2)k— (wherein k represents 0 or an integer of 1 to 3; R1 represents a saturated cyclic alkyl group having 3 to 7 carbon atoms or a saturated condensed cyclic alkyl group having 6 to 8 carbon atoms, and the group R1 may be substituted with a lower alkyl group having 1 to 4 carbon atoms) and the like, and Ar represents a condensed bicyclic group such as naphthalen-1-yl group, which has suppressing action on prostaglandin and leukotriene production and is useful for prophylactic and/or therapeutic treatment of various inflammatory diseases and the like caused by these lipid mediators.