69894-51-5

Basic information

• Product Name: 4-(prop-2-yn-1-yloxy)azetidin-2-one
• Synonyms: 2-Azetidinone, 4-(2-propynyloxy)-
• CAS NO: 69894-51-5
• Molecular Formula: C₆H₇NO₂
• Molecular Weight: 125.1253
• Mol File: 69894-51-5.mol

Chemical Properties

• Boiling Point: 342°C at 760 mmHg
• Flash Point: 160.6°C
• Density: 1.18g/cm³
• Vapor Pressure: 7.75E-05mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 4-(prop-2-yn-1-yloxy)azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(prop-2-yn-1-yloxy)azetidin-2-one(69894-51-5)
• EPA Substance Registry System: 4-(prop-2-yn-1-yloxy)azetidin-2-one(69894-51-5)

Safety Data

• Hazardous Substances Data: 69894-51-5(Hazardous Substances Data)

Upstream product

• 28562-53-0 4-acetoxy azetidinone 
• 107-19-7 propargyl alcohol 
• 28562-58-5 4-oxoazetidin-2-yl benzoate 

Downstream Products

• 85068-23-1 tert-butyl 3-phenyl-1-oxahomoceph-3-em-5α-carboxylate 
• 85082-65-1 tert-butyl <4-(propargyloxy)-2-oxoazetidin-1-yl>(phenylthio)acetate 
• 85068-24-2 tert-butyl 4-piperidyl-1-oxahomocepham-5-carboxylate 
• 69893-98-7 Hydroxy-(2-oxo-4-prop-2-ynyloxy-azetidin-1-yl)-acetic acid tert-butyl ester 

Relevant articles and documents

Design, synthesis and biological activity of novel enediynyl monocyclic β-lactams

Monocyclic β-lactams 1-3 substituted at C-4 with enediyne moiety have been synthesized via Pd(0) mediated coupling reaction. Their antibacterial activity against ampicillin-resistant E. coli have been tested.

4-Benzoyloxy-2-azetidinone, a convenient synthon for β-lactam intermediates

4 - Heterosubstituted - 2 - azetidenones were prepared in excellent yields from 4 - benzoyloxy - 2 - azetidenone (4), a much cheaper and stabler substrate compared to more common 4 - acetoxy - 2 - azetidenone (2).