698982-45-5

Usage

Uses

Used in Polymer and Plastics Industry:
Ethanone, 1,1'-[1,3-phenylenebis(methyleneoxy-3,1-phenylene)]bisis used as a crosslinking agent for the synthesis of polymers, enhancing their structural integrity and performance characteristics. Its presence in the production process allows for the creation of materials with improved mechanical properties and chemical resistance.
Used in Adhesives Production:
In the adhesives industry, Ethanone, 1,1'-[1,3-phenylenebis(methyleneoxy-3,1-phenylene)]bis- is employed to improve the bonding strength and durability of adhesive products. Its role as a crosslinking agent contributes to the formation of stronger and more stable adhesives that can withstand various environmental conditions.
Used in Coatings Production:
Ethanone, 1,1'-[1,3-phenylenebis(methyleneoxy-3,1-phenylene)]bisis utilized in the production of coatings to enhance their protective qualities and resistance to wear and tear. Ethanone, 1,1'-[1,3-phenylenebis(methyleneoxy-3,1-phenylene)]bis-'s crosslinking properties enable the development of coatings with increased hardness and resistance to chemicals, making them suitable for various applications, including automotive, industrial, and architectural coatings.
Used in Medical and Pharmaceutical Applications:
In the medical and pharmaceutical sectors, Ethanone, 1,1'-[1,3-phenylenebis(methyleneoxy-3,1-phenylene)]bisis used in the production of certain drugs and pharmaceutical products. Its unique chemical structure allows for the development of compounds with specific therapeutic properties, contributing to advancements in medicine and healthcare.
Overall, Ethanone, 1,1'-[1,3-phenylenebis(methyleneoxy-3,1-phenylene)]bisis a versatile chemical compound with applications spanning across various industries, from polymer and plastics to medical and pharmaceutical fields, where it plays a crucial role in enhancing the performance and properties of the final products.

Upstream product

• 608537-06-0 4-(3-{2-[3-(3-methoxycarbonyl-3-oxopropionyl)phenoxymethyl]benzyloxy}phenyl)-2,4-dioxobutyric acid methyl ester 
• 91-13-4 α,α'-dibromo-o-xylene 
• 95912-32-6 1-{3-[2-(3-acetylphenoxymethyl)benzyloxy]phenyl}ethanone 
• 95-47-6 o-xylene 

Downstream Products

• 698982-55-7 4-(3-{3-[3-(3-methoxycarbonyl-3-oxopropionyl)phenoxymethyl]benzyloxy}phenyl)-2,4-dioxobutyric acid methyl ester 

Relevant academic research and scientific papers

Rational Design and Synthesis of Novel Dimeric Diketoacid-Containing Inhibitors of HIV-1 Integrase: Implication for Binding to Two Metal Ions on the Active Site of Integrase

Discovery of diketoacid-containing compounds as HIV-1 integrase (IN) inhibitors played a major role in validating this enzyme as an important target for the development of therapeutics against HIV infection. In fact, S-1360, the first clinically used IN inhibitor containing a triazole ring as a bioisostere of a carboxylic acid moiety belongs to this class of compounds. To understand the role of divalent metal-chelating in the inhibition of IN (J. Med. Chem. 2002, 45, 5661-5670), we designed and synthesized a series of novel dimeric diketo-containing compounds with the notion that such dimeric compounds may simultaneously bind to two divalent metal ions on the active site of IN. We rationalized that the two diketo subunits separated by uniquely designed linkers can potentially chelate two metal ions that are either provided from one IN active site or two active sites juxtaposed together in a higher order tetramer. Herein, we show that all the new compounds are highly potent against purified IN with varied selectivity for strand transfer, and that some of the analogues exert potent inhibition of the cytopathic effect of HIV-1 in infected CEM cells. This study represents the first attempt to rationally target two divalent metal ions on the active site of IN and may have potential implications for the design of second generation diketoacid-containing class of inhibitors.