698983-87-8Relevant academic research and scientific papers
6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors
Bromidge, Steven M.,Bertani, Barbara,Borriello, Manuela,Faedo, Stefania,Gordon, Laurie J.,Granci, Enrica,Hill, Matthew,Marshall, Howard R.,Stasi, Luigi P.,Zucchelli, Valeria,Merlo, Giancarlo,Vesentini, Alessia,Watson, Jeannette M.,Zonzini, Laura
, p. 5653 - 5656 (2008)
Investigation of a series 6-[2-(4-aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones has led to the discovery of potent 5-HT1A/1B/1D receptor antagonists with and without additional SerT affinity. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization.
BENZOXAZINONE DERIVATIVES, PREPARATION THEREOF AND USES IN THE TREATMENT OF CNS AND OTHER DISORDERS
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Page 38, (2008/06/13)
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed:wherein A, R1, R2, R3, p, q, A and X are as defined in the specification. Preparation of the compounds and uses in the treatment of CNS and other disorders, including dep
