698984-51-9

Upstream product

• 1526-17-6 2-fluoro-6-nitrophenol 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 1350660-02-4 8-fluoro-3-methyl-4-[5-(3-morpholin-4-yl-phenoxy)pyrimidin-2-yl]-3,4-dihydro-2H-benzo[1,4]oxazine 
• 1350660-00-2 1-{3-[2-(8-fluoro-2,3-dihydro-benzo[1,4]oxazin-4-yl)-pyrimidin-5-yloxy]-phenyl}azetidin-3-ol 
• 1350659-99-2 4-(5-(3-bromophenoxy)pyrimidine-2-yl)-8-fluoro-3,4-dihydrobenzo[1,4]oxazine 
• 1350659-98-1 8-fluoro-4-[5-(3-N,N-dimethylaminophenoxy)pyrimidin-2-yl]-3,4-dihydro-2H-benzo[1,4]oxazine 
• 1350659-97-0 8-fluoro-4-[5-(3-methoxyphenoxy)pyrimidin-2-yl]-3,4-dihydro-2H-benzo[1,4]oxazine 
• 1350659-96-9 (S)-8-fluoro-4-[5-(3-(3-methylmorpholin-4-yl)phenoxy)pyrimidin-2-yl]-3,4-dihydro-2H-benzo[1,4]oxazine 
• 1350659-95-8 (R)-8-fluoro-4-[5-(3-(3-methylmorpholin-4-yl)phenoxy)pyrimidin-2-yl]-3,4-dihydro-2H-benzo[1,4]oxazine 
• 1350659-92-5 8-fluoro-4-[5-(3-morpholinophenoxy)-2-pyridyl]-3,4-dihydro-2H-benzo-[1,4]oxazine 
• 1350659-91-4 8-fluoro-4-[5-[3-(4-methylpiperazin-1-yl)phenoxy]pyrimidin-2-yl]-3,4-dihydro-2H-benzo[1,4]oxazine 
• 1350659-87-8 SEN₁₅₇₆ 
• 1350660-15-9 4-benzyl-8-fluoro-3-methyl-2,3-dihydro-1,4-benzoxazine 
• 1350660-14-8 4-benzyl-8-fluoro-1,4-benzoxazin-3-one 
• 1350660-12-6 4-[5-(benzyloxy)pyrimidin-2yl]-8-fluoro-3,4-dihydro-2H-benzo-[1,4]oxazine 
• 898832-40-1 8-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine 

Relevant academic research and scientific papers

6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors

Investigation of a series 6-[2-(4-aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones has led to the discovery of potent 5-HT1A/1B/1D receptor antagonists with and without additional SerT affinity. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization.