698984-96-2Relevant academic research and scientific papers
6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors
Bromidge, Steven M.,Bertani, Barbara,Borriello, Manuela,Faedo, Stefania,Gordon, Laurie J.,Granci, Enrica,Hill, Matthew,Marshall, Howard R.,Stasi, Luigi P.,Zucchelli, Valeria,Merlo, Giancarlo,Vesentini, Alessia,Watson, Jeannette M.,Zonzini, Laura
body text, p. 5653 - 5656 (2009/06/30)
Investigation of a series 6-[2-(4-aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones has led to the discovery of potent 5-HT1A/1B/1D receptor antagonists with and without additional SerT affinity. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization.
QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS
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Page/Page column 84, (2008/06/13)
Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
