699-05-8

Usage

Uses

(4-Fluorobenzyl)hydrazine can be used to treat pain and inflammation.

Upstream product

• 352-11-4 1-chloromethyl-4-fluorobenzene 

Downstream Products

• 137278-68-3 5-Amino-1-(4-fluorobenzyl)-4-cyanopyrazole 
• 137278-70-7 5-Amino-4-ethoxycarbonyl-1-(4-fluorobenzyl)pyrazole 
• 137279-16-4 1-(4-Fluorobenzyl)-7,8-dihydro-6H,9H-pyrazolo<3,4-b>quinoline-4,5-dione 
• 137278-87-6 4-Amino-1-(4-fluorobenzyl)-7,8-dihydro-6H-pyrazolo<3,4-b>quinolin-5-one 
• 137278-73-0 4-Cyano-1-(4-fluorobenzyl)-5-<(3-oxo-1-cyclohexen-1-yl)amino>pyrazole 
• 137279-11-9 7-(4-Fluorobenzyl)-4,5-dihydro-3H-isoxazolo<5,4,3-de>pyrazolo<3,4-b>quinoline 
• 137278-92-3 4-Amino-1-(4-fluorobenzyl)-5,6,7,8-tetrahydropyrazolo<3,4-b>quinolin-5-ol 
• 137278-83-2 4-Carboxy-1-(4-fluorobenzyl)-5-<(3-oxo-1-cyclohexen-1-yl)amino>pyrazole 
• 137278-78-5 4-Ethoxycarbonyl-1-(4-fluorobenzyl)-5-<(3-oxo-1-cyclohexen-1-yl)amino>pyrazole 
• 1003322-75-5 C₁₄H₁₄FN₃O₂S 
• 1003322-64-2 C₁₅H₁₅FN₂O₂S 
• 1202013-65-7 5,10-bis(benzyloxy)-3-(4-fluorobenzyl)-9,9,12-trimethyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione 
• 1204218-55-2 C₁₆H₁₇FN₂O₂ 
• 1204218-56-3 C₁₆H₁₇FN₂O₂ 

Relevant academic research and scientific papers

Synthesis and bioactivity study of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives

The discovery of new safe and effective pesticides is one of the main means of providing eco-friendly agricultural agents for modern crop protection. To identify new biological molecules based of the anthranilic diamide skeleton of the novel pesticide chlorantraniliprole, which acts on the ryanodine receptor and functional groups in acyl hydrazine insect growth regulators, more than 40 new compounds of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives were designed and synthesized. The structures of the new compounds were characterized using 1H nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HRMS), or electron impact mass spectrometry (EI-MS), and their biological activities at a concentration of 600 mg L -1 were determined against cotton aphid (Aphis gossypii Glover), carmine spider mite (Tetranychus cinnabarinus), and diamondback moth (Plutella xylostella). The results of a preliminary assay showed that compounds 6a-I-2 and 6d-III-4 maintained the lethal activity of anthranilic diamide against P. xylostella; compounds 6c-II-4, 6d-I-7, 6d-II-1, and 6d-III-5 exhibited good lethal activity against A. gossypii; and compounds 6a-II-1, 6a-III-1, 6b-I-7, 6c-I-1, and 6c-III-5 retained promising larvicidal activities against T. cinnabarinus. In subsequent further tests against T. cinnabarinus, compounds 6a-II-1, 6a-III-1, 6c-I-1, and 6c-III-5 showed an LC50 value of -1; especially, the LC50 of compound 6a-III-1 was only 27.9 mg L-1. In conclusion, the introduction of the functional fragment-substituted acyl hydrazine improved the acaricidal activity of the anthranilic diamide skeleton, and the halogen atom at X position and the methyl group at R1 play crucial roles in the biological activities of the compounds.

HIV INTEGRASE INHIBITORS

Tricyclic compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein G, T, R1, R2, R3A, R3B, R4A, R4B, R5A, R5B, R6A and R6B are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.