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6994-25-8

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6994-25-8 Usage

Chemical Properties

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General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Check Digit Verification of cas no

The CAS Registry Mumber 6994-25-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,9 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6994-25:
(6*6)+(5*9)+(4*9)+(3*4)+(2*2)+(1*5)=138
138 % 10 = 8
So 6994-25-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H9N3O2/c1-2-11-6(10)4-3-8-9-5(4)7/h3H,2H2,1H3,(H3,7,8,9)

6994-25-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
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  • Detail
  • Alfa Aesar

  • (A10882)  Ethyl 3-amino-1H-pyrazole-4-carboxylate, 99%   

  • 6994-25-8

  • 5g

  • 851.0CNY

  • Detail
  • Alfa Aesar

  • (A10882)  Ethyl 3-amino-1H-pyrazole-4-carboxylate, 99%   

  • 6994-25-8

  • 25g

  • 3936.0CNY

  • Detail
  • Alfa Aesar

  • (A10882)  Ethyl 3-amino-1H-pyrazole-4-carboxylate, 99%   

  • 6994-25-8

  • 100g

  • 13274.0CNY

  • Detail
  • Sigma-Aldrich

  • (A0350040)  AllopurinolimpurityD  European Pharmacopoeia (EP) Reference Standard

  • 6994-25-8

  • A0350040

  • 1,880.19CNY

  • Detail
  • USP

  • (1013046)  AllopurinolRelatedCompoundD  United States Pharmacopeia (USP) Reference Standard

  • 6994-25-8

  • 1013046-35MG

  • 14,578.20CNY

  • Detail
  • Aldrich

  • (A45009)  Ethyl3-aminopyrazole-4-carboxylate  98%

  • 6994-25-8

  • A45009-1G

  • 314.73CNY

  • Detail
  • Aldrich

  • (A45009)  Ethyl3-aminopyrazole-4-carboxylate  98%

  • 6994-25-8

  • A45009-5G

  • 906.75CNY

  • Detail

6994-25-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 3-amino-1H-pyrazole-4-carboxylate

1.2 Other means of identification

Product number -
Other names 1H-Pyrazole-4-carboxylic acid, 3-amino-, ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6994-25-8 SDS

6994-25-8Relevant articles and documents

Efficient, Protecting Group Free Kilogram-Scale Synthesis of the JAK1 Inhibitor GDC-4379

Angelaud, Remy,Burkhard, Johannes,Gosselin, Francis,Lao, David,Marx, Andreas,Ochsenbein, Miriam,Ranjan, Rohit,Stumpf, Andreas,Xu, Di

, p. 2537 - 2550 (2021/11/24)

The development of an improved kilogram-scale synthesis of the JAK1 inhibitorGDC-4379for the treatment of asthma is described. The new process is highlighted by a step-economical construction of a 3-substituted-4-aminopyrazole employing a telescoped oximation and hydrazine condensation of a 1,3-dielectrophile to generate nitrosopyrazole and a novel copper-catalyzed NaBH4reduction of the nitroso group. The endgame process features an amidation of aminopyrazole with acid chloride under Schotten-Baumann conditions to provide access to the penultimate intermediate. A selective N-1 alkylation of the pyrazole moiety was accomplished under phase-transfer conditions, which deliveredGDC-4379with a defined particle-size distribution suitable for micronization after recrystallization and wet milling.

MACROCYCLIC SULFONYLAMIDE DERIVATIVES USEFUL AS NLRP3 INHIBITORS

-

Page/Page column 164, (2021/02/26)

The present invention relates to macrocyclic compounds, such as macrocyclic sulfonyl amides. The present invention further relates to associated salts, solvates, prodrugs and pharmaceutical compositions, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.

A class of FLT3 kinase inhibitors, preparation and application thereof

-

Paragraph 0158; 0161-0164, (2020/06/20)

The invention relates to a class of FLT3 kinase inhibitors, preparation and application thereof, wherein specifically the compound has a structure represented by a formula (I), and all groups and substituents are defined in the specification. The invention also discloses a preparation method of the compound, and application of the compound in inhibition of FLT3.

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