69943-47-1

Basic information

• Product Name: (2-Chloro-4-fluorophenyl)phenylmethanone
• Synonyms: (2-Chloro-4-fluorophenyl)phenylmethanone
• CAS NO: 69943-47-1
• Molecular Formula: C₁₃H₈ClFO
• Molecular Weight: 234.65
• Mol File: 69943-47-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 332.2°C at 760 mmHg
• Flash Point: 154.7°C
• Appearance: /
• Density: 1.277g/cm³
• Vapor Pressure: 0.000148mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: (2-Chloro-4-fluorophenyl)phenylmethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Chloro-4-fluorophenyl)phenylmethanone(69943-47-1)
• EPA Substance Registry System: (2-Chloro-4-fluorophenyl)phenylmethanone(69943-47-1)

Safety Data

• Hazardous Substances Data: 69943-47-1(Hazardous Substances Data)

Usage

General Description

(2-Chloro-4-fluorophenyl)phenylmethanone, also known as 4'-Chloro-4-fluorodiphenyl ketone, is a chemical compound with the molecular formula C13H8ClFO. It is a ketone derivative that consists of a phenyl group with a (2-chloro-4-fluorophenyl) substituent. (2-Chloro-4-fluorophenyl)phenylmethanone is used in organic synthesis and pharmaceutical research. It has applications in the development of pharmaceutical drugs, agrochemicals, and materials science. The chemical is also used as an intermediate in the production of various organic compounds and has potential applications in the fields of medicine and technology. Additionally, it is important to handle this compound with caution, as it may have hazardous effects on human health and the environment.

InChI:InChI=1/C13H8ClFO/c14-12-8-10(15)6-7-11(12)13(16)9-4-2-1-3-5-9/h1-8H

Upstream product

• 67-66-3 chloroform 
• 101335-11-9 2-chloro-4-fluoro-1-iodobenzene 
• 98-80-6 phenylboronic acid 
• 1094791-43-1 C₁₃H₁₀ClFO 
• 108-86-1 bromobenzene 
• 84194-36-5 2-chloro-4-fluorobenzaldehyde 
• 1620217-67-5 1-benzyl-2-chloro-4-fluorobenzene 
• 208186-84-9 (2-chloro-4-fluorophenyl)methanol 
• 2252-51-9 2-choro-4-fluorobenzoic acid 
• 21900-54-9 2-chloro-4-fluorobenzoyl chloride 
• 71-43-2 benzene 

Downstream Products

• 875479-24-6 1-(2-chloro-4-pyrrolidinophenyl)-1-phenylprop-2-yn-1-ol 
• 875479-20-2 2-chloro-4-pyrrolidinobenzophenone 

Relevant articles and documents

Transition-metal-free carbonylation of aryl halides with arylboronic acids by utilizing stoichiometric CHCl3 as the carbon monoxide-precursor

Under transition-metal-free conditions, carbonylative Suzuki couplings of aryl halides with arylboronic acid using stoichiometric CHCl3 as the carbonyl source has been developed. The simple, efficient, and environmentally benign method was successfully applied to the synthesis of Fenofibric acid, naphthyl phenstatin, and carbon-13 labeled biaryl ketone.

Synthesis of structurally diverse diarylketones through the diarylmethyl sp3 C-H oxidation

Under open-flask conditions, an efficient method to assemble a series of diversely functionalized diarylketones in the presence of commercially available NBS has been developed. Yields of up to 99% have been achieved employing diarylmethanes as starting material. Based on 18O-labeled experiment, the addition of stoichiometric water eventually leads to excellent yields in all carbonylation cases.

The synthesis and electronic absorption spectra of 3-phenyl-3(4- pyrrolidino-2-substituted phenyl)-3H-naphtho[2,1-b]pyrans: Further exploration of the ortho substituent effect

Introduction of a substituent into a sterically demanding 2-position of a 3-(4-pyrrolidinophenyl) ring of a 3,3-diaryl-3H-naphtho[2,1-b]pyran results in the generation of an additional short wavelength absorption band leading to organic photochromes that