69950-00-1 Usage
Description
2-Amino-5-thiazolethiol, with the chemical formula C3H5N3S, is a thiol derivative of thiazole. It has a molecular weight of 119.16 g/mol and is known for its strong odor. 2-AMINO-5-THIAZOLETHIOL is commonly used in organic synthesis and pharmaceutical research, and has potential applications in drug development and the production of thiourea derivatives. Due to its potential toxicity, it should be handled with caution.
Uses
Used in Pharmaceutical Research:
2-Amino-5-thiazolethiol is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical properties allow it to be incorporated into the development of new drugs with potential therapeutic benefits.
Used in Organic Synthesis:
As a thiol derivative, 2-Amino-5-thiazolethiol is used in organic synthesis for the preparation of a wide range of chemical compounds. Its reactivity and versatility make it a valuable component in the creation of specialized chemicals.
Used in the Production of Thiourea Derivatives:
2-Amino-5-thiazolethiol is utilized in the manufacturing process of thiourea derivatives, which have various applications in the chemical industry, including as pesticides, pharmaceuticals, and dyes.
Used as a Reagent in Organic Reactions:
Due to its strong reactivity, 2-Amino-5-thiazolethiol serves as a reagent in various organic reactions, facilitating the formation of desired products and contributing to the advancement of chemical research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 69950-00-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,9,5 and 0 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 69950-00:
(7*6)+(6*9)+(5*9)+(4*5)+(3*0)+(2*0)+(1*0)=161
161 % 10 = 1
So 69950-00-1 is a valid CAS Registry Number.
69950-00-1Relevant articles and documents
Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13
Liu, Yao,Hao, Mingfeng,Leggett, Alan L.,Gao, Yang,Ficarro, Scott B.,Che, Jianwei,He, Zhixiang,Olson, Calla M.,Marto, Jarrod A.,Kwiatkowski, Nicholas P.,Zhang, Tinghu,Gray, Nathanael S.
, p. 6708 - 6726 (2020)
Genetic depletion of cyclin-dependent kinase 12 (CDK12) or selective inhibition of an analog-sensitive CDK12 reduces DNA damage repair gene expression, but selective inhibition of endogenous CDK12 is difficult. Here, we report the development of MFH290, a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent kinome selectivity, inhibits the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II), and reduces the expression of key DNA damage repair genes. Importantly, these effects were demonstrated to be CDK12-dependent as mutation of Cys-1039 rendered the kinase refractory to MFH290 and restored Pol II CTD phosphorylation and DNA damage repair gene expression. Consistent with its effect on DNA damage repair gene expression, MFH290 augments the antiproliferative effect of the PARP inhibitor olaparib.
