69960-27-6Relevant academic research and scientific papers
Facile installation of a hydroxyalkyl group into hydroxyanthraquinones and aminoanthraquinones through the modified Marschalk reaction
Zhao, Li-Ming,Ma, Feng-Yan,Jin, Hai-Shan,Ma, Jiao,Wang, Huan,Fu, Chuan-Zhao
, p. 7193 - 7199 (2013)
1,4-Dihydroxyanthraquinones are widely featured in numerous natural products and drugs. It is important to be able to functionalize the 1,4-dihydroxyanthraquinone skeleton through a simple yet efficient transformation, which could be potentially useful for the drug discovery process. We describe herein a simple and efficient method to derivatize 1,4-dihydroxyanthraquinone by using a modified Marschalk reaction. This method provides a clear advantage over traditional approaches, which often require the protection and deprotection of the OH groups. We also demonstrate the applicability of this reaction to other hydroxyanthraquinones and aminoanthraquinones. We describe herein a simple method for the derivatization of 1,4-dihydroxyanthraquinone through a modified Marschalk reaction. This method provides a clear advantage over traditional approaches, which often require the protection and deprotection of the OH groups. We have also demonstrated that this reaction is applicable to other anthraquinones. Copyright
