69964-53-0

Upstream product

• 3528-17-4 2,3-dihydro-4H-[1]benzothiopyran-4-one 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 135521-77-6 3-Methoxy-1-p-tolyl-10H-9-thia-4-aza-phenanthrene-2-carbonitrile 
• 29309-05-5 1-Oxo-3-[1-p-tolyl-meth-(Z)-ylidene]-1λ⁴-thiochroman-4-one 
• 1373520-32-1 (2R,3S,3aR)-tert-butyl 3-p-tolyl-2,3,3a,4-tetrahydrothiochromeno[4,3-b]pyrrole-2-carboxylate 
• 137985-62-7 4-(p-tolyl)-3,4-dihydro-1H-thiochromeno[4,3-d]pyrimidine-2(5H)-thione 
• 137985-58-1 1-p-Tolyl-1H,10H-2,9-dithia-4-aza-phenanthren-3-ylamine 
• 76238-59-0 3-[1-p-Tolyl-meth-(Z)-ylidene]-thiochroman-4-ol 

Relevant academic research and scientific papers

I2/TBHP mediated diastereoselective synthesis of spiroaziridines

Eventhough spiroheterocycles are considered as emerging drug candidates, synthesis of spiroaziridines has not been well explored so far. Herein, we disclose an efficient I2/TBHP mediated diastereoselective synthesis of N-alkyl spiroaziridines from primary amines and easily accessible α,β-unsaturated ketones. The reaction is also compatible for the synthesis of 2-aroylaziridines.

Green chemistry preparation of MgO nanopowders: efficient catalyst for the synthesis of thiochromeno[4,3-b]pyran and thiopyrano[4,3-b]pyran derivatives

A mild and efficient method for the synthesis of thiochro meno[4,3-b]pyran and thiopyrano[4,3-b]pyran derivatives using MgO nanopowders as a catalyst is described. The MgO nanopowders were prepared via a green biosynthesis method using an extract of Rosma

Synthesis of novel tricyclic heterocyclic compounds as potential anticancer agents using chromanone and thiochromanone as synthons

The arylmethylene of benzopyrane or benzothiopyrane 3,4 have been synthesized and condensed with hydrazine, guanidine and thiourea to yield pyrazole 5-8, aminopyrimidine 9,10 and thioxopyrimidine derivatives 11,12, respectively. Compounds 3 or 4 on treatment with malononitrile in the presence of ammonium acetate/acetic acid or in the presence of piperidine/ methanol to yield benzopyrano- and benzothiopyranopyridine 13,14 and benzopyrano- and benzothiopyrane 15,16, respectively. The oxirane of compound 3 is prepared and condensed with CS2 to yield the tricyclic system, thioxothienobenzopyrane 21. Ylidenemalononitrile for the ketone 1 and 2 are synthesized and condensed with aromatic aldehyde in presence of ammonium acetate/acetic acid to yield benzopyranopyridine and benzothiopyranopyridine derivatives 24,25, respectively, which are the isomer of compounds 13,14. Ylidenemalononitrile on condensation with phenylisothiocyanate yields benzo-pyrano- and benzothiopyranothioxopyridine 28,29, respectively.

Reactivity of α-arylidene benzoheteracyclanone dibromides toward azide ion: An effective approach to 3-(α-substituted-benzyl)chromones and -1-thiochromones

Treatment of dibromides of 3-arylidenechromanones and -1-thiochromanones with sodium azide resulted in the formation of 3-(α-azidobenzyl)chromones and -1-thiochromones whereas dibromides having no antiperiplanar vicinal hydrogen in the ring such as flavanone, 1-thioflavanone and benzosuberone derivatives afforded only the parent enones by bromine elimination. Evidence supported the intermediacy of 3-(α-bromobenzyl)chromones and -1-thiochromones in this reaction. These postulated intermediates were prepared in an independent way and transformed into azides in high yield.