69984-27-6

Upstream product

• 111-44-4 3-oxa-1,5-dichloropentane 
• 99-96-7 4-hydroxy-benzoic acid 
• 15880-73-6 C₂₀H₂₂O₇ 

Downstream Products

• 1080623-04-6 [Cd(1,4-bis(1H-imidazol-1-yl)butane)(4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))dibenzoate)] 
• 1492928-90-1 C₁₈H₁₆O₇^(2-)*Co⁽²⁺⁾*C₁₂H₁₀N₄*H₂O 

Relevant academic research and scientific papers

Antiprotozoal activities of symmetrical bishydroxamic acids

Symmetrical bishydroxamic acids along with their sodium salts containing an alkyl spacer between two aromatic rings were synthesized, and their antiparasitic activities were evaluated. Bishydroxamic acids were conveniently prepared from the alkylation of methyl 4-hydroxybenzoate with various dihalo-alkane, -alkene, and -ether followed by reaction with hydroxylamine. Surprisingly, the bishydroxamic acids and their sodium salts possess strong inhibitory activities against Plasmodium falciparum parasites with IC 50 values in the range of 0.26-3.2 μM. Bishydroxamic acid 3 and its sodium salt 12 also inhibit the growth of Leishmania donovani, albeit at higher concentrations. The corresponding biscarboxylic acids and bismethyl esters are inactive. Presumably, the ability of bishydroxamic acids to complex with metallic iron in hemoglobin may be responsible for antimalarial activity of these compounds.

FROM CONVENTIONAL TO LIQUID CRYSTALLINE POLYESTERS

To obtain liquid crystalline copolyesters with improved thermal behavior, p-acetoxybenzoyloxy-benzoic acid and a variety of dicarboxylic acids derived from p-hydroxybenzoic acid in combination with acetylated hydroquinone derivatives have been used as poly(ethylene terephthalate) (PETP) modifiers.The influence of the modifier structure on thermotropic properties of the copolyesters and results of dynamic mechanical measurements are discussed.