69986-21-6Relevant academic research and scientific papers
Process for preparing isomerically pure prodrugs of proton pump inhibitors
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Page/Page column 37, (2010/02/10)
Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description.
Prodrugs of proton pump inhibitors
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, (2008/06/13)
Prodrugs of the pyridyl methyl sulfinyl benzimidazole type proton pump inhibitor drugs have a hydrolyzable arylsulfonyl or heteroarylsulfonyl group attached to the benzimidazole nitrogen. The prodrugs of the invention hydrolyze under physiological conditions to provide the proton pump inhibitors with a half life measurable in hours, and are capable of providing sustained plasma concentrations of the proton pump inhibitor drugs for longer time than presently used drugs. The generation of the proton pump inhibitor drugs from the prodrugs of the invention under physiological conditions allows for more effective treatment of several diseases and conditions caused by gastric acid secretion.
NEW CHLOROMETHYLSULFONYL SUBSTITUTED PHENOXYACETIC ACID DERIVATIVES
Ejmocki, Zdzislaw,Krasowska, Barbara,Olczak, Izabela,Eckstein, Zygmunt
, p. 2153 - 2159 (2007/10/02)
A description is given of studies on synthesis of phenoxyacetic acid derivatives substituted in the benzene ring by a chloromethylsulfonic group.
