70-10-0

Basic information

• Product Name: 6-CHLORO-1,2-BENZISOTHIAZOL-3(2H)-ONE
• Synonyms: ticlatone;FER1443,Landromil,Ticlaton,Ticlatone,3-Hydroxy-6-chloro-1,2-benzisothiazole;Landromill;6-chloro-1,2-benzothiazol-3-one;6-Chlorobenzo[d]isothiazol-3(2H)-one;6-CHLORO-1,2-BENZISOTHIAZOL-3(2H)-ONE;6-chloro-1,2-benzisothiazolin-3-one;6-chloro-1,2-benzisothiazolone
• CAS NO: 70-10-0
• Molecular Formula: C₇H₄ClNOS
• Molecular Weight: 185.63076
• Product Categories: Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 70-10-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 270-272°C
• Appearance: /
• Density: 1.515g/cm³
• Refractive Index: 1.669
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.72±0.20(Predicted)
• CAS DataBase Reference: 6-CHLORO-1,2-BENZISOTHIAZOL-3(2H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-1,2-BENZISOTHIAZOL-3(2H)-ONE(70-10-0)
• EPA Substance Registry System: 6-CHLORO-1,2-BENZISOTHIAZOL-3(2H)-ONE(70-10-0)

Safety Data

• Hazardous Substances Data: 70-10-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to Light Beige Solid

Uses

Different sources of media describe the Uses of 70-10-0 differently. You can refer to the following data:
1. Ticlid (Roche).
2. 6-Chloro-1,2-benzisothiazol-3(2H)-one (cas# 70-10-0) is a compound useful in organic synthesis.

Brand name

Ticlopidine is INN and BAN.

InChI:InChI=1/C7H4ClNOS/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)

Upstream product

• 40183-35-5 2-(benzylthio)-4-chlorobenzoic acid 
• 50-84-0 2,4 dichlorobenzoic acid 
• 40183-55-9 2-(benzylthio)-4-chlorobenzoic acid chloride 
• 942319-20-2 4-chloro-2-iodobenzamide 
• 176107-21-4 4-chloro-2-(methylthio)benzonitrile 
• 19993-69-2 2,2'-dithiobis(3-chlorobenzoyl)chloride 
• 19993-68-1 bis(2-carboxy-6-chlorophenyl) disulphide 
• 52948-12-6 Methyl 4-chloro-2-mercaptobenzoate 

Downstream Products

• 131540-87-9 6-chloro-1,2-benzisothiazol-3-yl piperazine 
• 19331-46-5 N-[6-Chloro-benzo[1,2]dithiol-(3Z)-ylidene]-benzamide 

Relevant articles and documents

Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics

A series of novel benzisothiazolylpiperazine derivatives combining potent dopamine D2and D3, and serotonin 5-HT1Aand 5-HT2Areceptor properties were synthesized and evaluated for their potential antipsychotic properties. The most-promising derivative was 9j. The unique pharmacological features of 9j were a high affinity for D2, D3, 5-HT1A, and 5-HT2Areceptors, together with a 20-fold selectivity for the D3versus D2subtype, and a low affinity for muscarinic M1(reducing the risk of anticholinergic side effects), and for hERG channels (reducing incidence of QT interval prolongation). In animal behavioral models, 9j inhibited the locomotor-stimulating effects of phencyclidine, blocked conditioned avoidance response, and improved the cognitive deficit in the novel object recognition tests in rats. 9j exhibited a low potential for catalepsy, consistent with results with risperidone. In addition, favorable brain penetration of 9j in rats was detected. These studies have demonstrated that 9j is a potential atypical antipsychotic candidate.

1,2-BENZISOTHIAZOL-3-ONE COMPOUND PRODUCTION METHOD

The present invention provides a method for producing 1,2-benzisothiazol-3-one compounds by reacting a 2-(alkylthio)benzonitrile compound with a halogenating agent in the presence of water, the method being characterized in that the reaction proceeds while the halogenating agent and water are gradually and simultaneously added to a reaction system containing the 2-(alkylthio)benzonitrile compound. The invention allows the simple and economical production of highly pure 1,2-benzisothiazol-3-one compounds, which are useful as antimicrobial agents, antifungal agents, etc.

9-Azabicyclo[3.3.1]nonane derivatives

The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.