700-02-7

Usage

Uses

Used in Biochemical Research:
ADENINE N(1)-OXIDE MONOHYDRATE, 98 is used as a research compound for studying the structure, function, and interactions of nucleic acids in biochemical processes. Its high purity ensures reliable and consistent results in laboratory experiments.
Used in Molecular Biology:
In the field of molecular biology, ADENINE N(1)-OXIDE MONOHYDRATE, 98 serves as an essential component in the synthesis and manipulation of nucleic acids, enabling researchers to explore the mechanisms of gene expression, regulation, and replication.
Used in Pharmaceutical Research:
ADENINE N(1)-OXIDE MONOHYDRATE, 98 is utilized as a key building block in the development of new drugs and therapeutic agents targeting nucleic acid-related diseases. Its unique properties and high purity make it suitable for use in drug discovery and optimization processes.
Used in Diagnostic Applications:
In diagnostic laboratories, ADENINE N(1)-OXIDE MONOHYDRATE, 98 can be employed as a reference compound or standard for the development and validation of assays and tests related to nucleic acid analysis, ensuring accurate and reliable results.
Used in Educational Settings:
ADENINE N(1)-OXIDE MONOHYDRATE, 98 can be utilized as a teaching aid in educational institutions, providing students with hands-on experience in working with nucleobases and understanding their role in the structure and function of nucleic acids.

InChI:InChI=1/C5H5N5O/c6-4-3-5(8-1-7-3)9-2-10(4)11/h1-2H,6H2,(H,7,8,9)

Upstream product

• 73-24-5 7H-purin-6-ylamine 
• 66224-66-6 adenine 

Downstream Products

• 5167-14-6 hypoxanthine 1-N-oxide 
• 101622-53-1 2-chloro-6-benzylamino-9-methylpurine 
• 39639-47-9 N⁶-benzyl-2-chloroadenine 
• 5451-40-1 2,6 dichloropurine 
• 186692-41-1 2-chloro-6-phenylmethylamino-9-iso-propylpurine 

Relevant academic research and scientific papers

Synthesis of (+)-agelasine C. A structural revision

An efficient synthesis of (+)-agelasine C has been achieved from ent-halimic acid. The structure and absolute configuration of the natural product (-)-agelasine C was established and a structure for epi-agelasine C, is proposed.

Microsomal N-oxygenation of adenine to adenine 1-N-oxide

During investigations on the N-oxygenation of adenine (1) the enzymatic formation of adenine 1-N-oxide 3 was demonstrated for the first time. The identity of this metabolite was confirmed by its chromatographic behaviour and UV-spectrum recorded after HPLC separation. Adenine 1-N-oxide (3) and similar oxygenated derivatives of adenine were synthesized as reference substances. The enzymatic formation of 3 exhibits the typical characteristics of a reaction catalysed by microsomal mono-oxygenases. In induction experiments, an increase in the rate of formation of after 3 pretreatment with phenobarbital was observed. A participation of those isoenzymes of the cytochrome P-450 enzyme system which can be induced by phenobarbital is assumed.

Synthesis and biological activities of C-2, N-9 substituted 6- benzylaminopurine derivatives as cyclin-dependent kinase inhibitor

In this study, C-2, N-9 substituted 6-benzylaminopurine derivatives were synthesized and their inhibitory effects on cyclin-dependent kinase (CDK2) were evaluated. The effect of substituents at the C-2 and N-9 positions of substituted purine was investigated. Among the compounds tested, compound 7b- iii (6-benzylamino-2-thiomorpholinyl-9-isopropylpurine) was the most active inhibitor (IC50 = 0.9 μM). Compound 7b-iii showed 10-fold higher activity compared to olomoucine and almost the same activity as roscovitine. Results from structure-activity relationship studies should allow the design of more potent and selective CDK inhibitors, which may provide an effective therapy for cancer or other CDK dependent diseases.