700-52-7

Usage

Uses

Used in Pharmaceutical Synthesis:
7-METHYL-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in the molecular structure of these compounds can contribute to their biological activity and therapeutic efficacy.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 7-METHYL-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE is utilized as a building block for the design and development of new drugs. Its unique fused ring system allows for the exploration of novel chemical space and the potential discovery of innovative therapeutic agents.
Used in Drug Discovery for Various Therapeutic Applications:
7-METHYL-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE is employed in drug discovery efforts targeting a wide array of therapeutic areas. Its incorporation into drug candidates can potentially address unmet medical needs and contribute to advancements in healthcare.

Upstream product

• 96-50-4 2-thiazolylamine 
• 141-97-9 ethyl acetoacetate 
• 623-46-1 1,2-dichloro-2-ethoxyethane 
• 17356-08-0 thiourea 
• 135351-18-7 (E)-1,1,1-trichloro-4-methoxypent-3-en-2-one 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 85811-40-1 7-[(E)-2-(4-Chlorophenyl)vinyl]-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one 
• 1192871-74-1 4-(7-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-6-yl)benzonitrile 
• 1192871-75-2 7-methyl-6-(4-trifluoromethylphenyl)thiazolo[3,2-a]pyrimidin-5-one 

Relevant academic research and scientific papers

Practical synthesis of 4H-pyrido[1, 2-a]pyrimidin-4-ones using ethylene glycol as a promoting solvent

A simple and useful protocol leading to different 4H-pyrido[1, 2-a] pyrimidin-4-ones have been established by cyclization of various 2-amino pyridines with β-oxo ester or alkynoate. The use of ethylene glycol was demonstrated to facilitate this condensati

Antitubercular Activity and Synergistic Study of Novel Pyrazole Derivatives

A series of 20 novel pyrazole derivatives were designed and prepared, characterized by 1H-NMR, mass spectra (ES-MS), 13C-NMR, and elemental analysis. The synthesized compounds were then evaluated for their growth inhibitory activity

Thiazolo[3,2-a] Pyrimidones as a Novel Anti-TB Agents

A series of novel thiazolo pyrimidine derivatives were designed, synthesized, and assessed for their in vitro anti-mycobacterial activities. All hybrids displayed considerable antitubercular activities against primary Mycobacterium smegmatis mc2 155 screening and successive Mycobacterium tuberculosis H37Rv. In particular, the hybrid entities 13 and 14 (minimum inhibitory concentration: 47 and 39?μg/mL) were found to be equipotent candidates with first-line antitubercular agent rifampicin, which could act as a lead for further optimization.

Solvent-free synthesis of 4H-Pyrido[1,2-a]pyrimidin-4-ones catalyzed by BiCl3: A green route to a privileged backbone

An extensive array of 4H-pyrido[1,2-a]pyrimidin-4-ones have been synthesized from commercially available 2-aminopyridines and β-oxo esters with excellent yields under solvent-free conditions. The reaction, catalyzed by cheap and nontoxic BiCl3,

Synthesis of 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one derivatives

The reaction of 2-aminothiazoles with ethyl acetoacetate in acetic or polyphosphoric acid gave a series of 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one derivatives which were nitrated with a mixture of nitric and sulfuric acid to 6-nitro-5H-[1,3]thiazolo[3,2-a]

FUSED PYRIMIDINEONE COMPOUNDS AS TRPV3 MODULATORS

The present invention provides transient receptor potential vanilloid (TRPV) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are pro

Reaction of N-aryl-3-oxobutanethioamides with 2-amino-1,3-thiazole and 2-amino-1,3-benzothiazole

N-Aryl-3-oxobutanethioamides react with 2-amino-1,3-thiazole (2-amino-1,3-benzothiazole) in acetic acid to give mixtures of 7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-5-thione (2-methyl-4H-pyrimido-[2,1- b][1,3]benzothiazole-4-thione) and 5-arylimino-7-me

β-Alkoxyvinyl trichloromethyl ketones as N-heterocyclic acylating agent. A new access to 5H-thiazolo[3,2-a]pyrimidin-5-ones

Using trichloromethyl substituent as convenient leaving group for the synthesis of interesting bi-heterocyclic compounds, a series of 6-methyl- and 7-alkyl(aryl)-5H-thiazolo[3,2-a]pyrimidin-5-ones, where alkyl=methyl, n-propyl, isopropyl, isobutyl, n-hexyl, isopentyl and aryl=phenyl, 4-toluyl, 4-chlorophenyl, 4-bromophenyl, 4-methoxyphenyl was obtained from a simple and regiospecific reaction of 4-alkoxy-1,1,1-trichloro-3-alken-2-ones with 2-aminothiazole in good yield (45-89%).

N-SUBSTITUTED AZABICYCLOALKANE DERIVATIVES, THEIR PREPARATION AND USE

Compounds of the formula I STR1 where B, R 1, R 2, n, R. sup.3, A, X, Y and Z have the meanings stated in the description, and their preparation are described. The novel ompounds are suitable for controlling diseases.

N-substituted azabicycloheptane derivatives

Abstract of the Disclosure: Compounds of the formula I STR1 where R1, R2, n , R3, A, X, Y and Z have the meanings stated in the description, and the preparation thereof are described. The novel compounds are suitable for controlling diseases , i.e., as neuroleptics, antidepressants, sedatives, hypnotics, CNS protectives or muscle relaxants.