Basic information

Product Name: QUAZINONE
Synonyms: QUAZINONE;R 13-6438;RO 13-6438;(3R)-6-Chloro-1,5-dihydro-3-methylimidazo[2,1-b]quinazolin-2(3H)-one;Posicor;Imidazo(2,1-B)quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-, (R)-;Quazinona;Quazinona [spanish]
CAS NO:70018-51-8
Molecular Formula: C11H10ClN3O
Molecular Weight: 235.67
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: 345.6°C at 760 mmHg
Flash Point: 162.8°C
Appearance: white/
Density: 1.57g/cm³
Vapor Pressure: 6.1E-05mmHg at 25°C
Refractive Index: 1.746
Storage Temp.: RT
Solubility: ethanol: soluble1mg/mL
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
CAS DataBase Reference: QUAZINONE(CAS DataBase Reference)
NIST Chemistry Reference: QUAZINONE(70018-51-8)
EPA Substance Registry System: QUAZINONE(70018-51-8)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 70018-51-8(Hazardous Substances Data)

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SDS
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70018-51-8 Usage

Uses

Used in Pharmaceutical Industry:
QUAZINONE is used as a cardiotonic agent for its ability to improve heart function and increase the force of heart contractions. This makes it a valuable compound for the treatment of heart-related conditions.
Additionally, QUAZINONE is used as a phosphodiesterase inhibitor for its vasodilating properties, which can help in the treatment of various cardiovascular diseases by promoting the relaxation of blood vessel walls and improving blood flow.
Used in Cardiovascular Applications:
QUAZINONE is used as a novel cardiotonic agent for enhancing heart function and providing relief from heart-related conditions. Its vasodilating properties also contribute to its effectiveness in treating cardiovascular diseases by improving blood flow and reducing the workload on the heart.

References

1) Eigenmann et al. (1984) Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent with vasodilating properties; J. Cardiovasc. Pharmacol., 6 511 2) Holck et al. (1984) Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties; J. Cardiovasc. Pharmacol. 6 520

Check Digit Verification of cas no

The CAS Registry Mumber 70018-51-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,0,1 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 70018-51:
(7*7)+(6*0)+(5*0)+(4*1)+(3*8)+(2*5)+(1*1)=88
88 % 10 = 8
So 70018-51-8 is a valid CAS Registry Number.

InChI:InChI=1/C11H10ClN3O/c1-6-10(16)14-11-13-9-4-2-3-8(12)7(9)5-15(6)11/h2-4,6H,5H2,1H3,(H,13,14,16)/t6-/m1/s1

70018-51-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name	QUAZINONE

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:70018-51-8 SDS

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