70027-38-2Relevant academic research and scientific papers
Synthesis of pyrazolothiazole and pyrimidinothiazole deriovatives
Chande, Madhukar S.,Bhandari, Jayesh D.,Karyekar, Anita S.
, p. 985 - 989 (2007/10/03)
The reaction of 4-bromo-1,3-substituted-pyrazolin-5-one (1) with thiocarbamides gives 2-mino-4,6-substituted-pyrazolothiazoles (3) which on treatment with isothiocyanates yield 2-(N'-alkyl/arylthioureido)-4,6-substituted-pyrazolothiazoles (5).An alternate one step synthesis of 5 has also been achieved by the reaction of 1 with dithiobiurets (4) in the presence of pyridine.Similarly, 5-bromobarbituric acid (6) on reaction with thiocarbamides in refluxing ethanol in the presence of base affords 2-alkyl/aryl-4H,6H-pyrimidino-thiazole-5,7-diones (7)which on treatment with isothiocyanates yields 2-(N'-alkyl/arylthioureido)-4H,6H-pyrimidinothiazole-5,7-diones (8).Compound 8 has also been synthesized in one step by the reaction of 6 with substituted dithiobiurets (4).
