7003-65-8Relevant academic research and scientific papers
PROTEIN KINASE C AGONISTS
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Paragraph 0434, (2020/09/12)
The present disclosure relates generally to certain diacylglycerol lactone compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions dis
Synthesis of aromatic functionalized cage-rearranged silsesquioxanes (T8, T10, and T12) via nucleophilic substitution reactions
Chimjarn, Supansa,Kunthom, Rungthip,Chancharone, Prapassorn,Sodkhomkhum, Rapheepraew,Sangtrirutnugul, Preeyanuch,Ervithayasuporn, Vuthichai
supporting information, p. 916 - 919 (2015/02/19)
Organic-inorganic hybrid nano-building blocks of aromatic nitro-, aldehyde-, and bromo-functionalized polyhedral oligomeric silsesquioxanes were easily prepared through nucleophilic substitutions, starting from the reactions between octakis(3-chloropropyl)octasilsesquioxane and phenoxide derivatives. These phenoxide anions not only supply the substitution functions to a silsesquioxane cage, but can also induce a cage-rearrangement leading to the formation of octa-, deca-, and dodecahedral silsesquioxane cages. This journal is
Do electrostatic interactions with positively charged active site groups tighten the transition state for enzymatic phosphoryl transfer?
Nikolic-Hughes, Ivana,Rees, Douglas C.,Herschlag, Daniel
, p. 11814 - 11819 (2007/10/03)
The effect of electrostatic interactions on the transition-state character for enzymatic phosphoryl transfer has been a subject of much debate. In this work, we investigate the transition state for alkaline phosphatase (AP) using linear free-energy relationships (LFERs). We determined fcat/K M for a series of aryl sulfate ester monoanions to obtain the Bronsted coefficient, βIg, and compared the value to that obtained previously for a series of aryl phosphorothioate ester dianion substrates. Despite the difference in substrate charge, the observed Bronsted coefficients for AP-catalyzed aryl sulfate and aryl phosphorothioate hydrolysis (-0.76 ± 0.14 and -0.77 ± 0.10, respectively) are strikingly similar, with steric effects being responsible for the uncertainties in these values. Aryl sulfates and aryl phosphates react via similar loose transition states in solution. These observations suggest an apparent equivalency of the transition states for phosphorothioate and sulfate hydrolysis reactions at the AP active site and, thus, negligible effects of active site electrostatic interactions on charge distribution in the transition state.
Evaluation of the Polar-inductive and Mesomeric Effects exerted by para-Substituted Phenyl Rings on Contiguous Functionalities
Barchiesi, Emma,Bradamante, Silvia,Pagani, Giorgio A.
, p. 1091 - 1096 (2007/10/02)
The para C-13 shifts of the phenyl ring in PhCH2Ar (I) is used as a monitor to evaluate, in terms of the previously defined ?IB constants, the polar-inductive effect exerted by some para-substituted aryl rings.Analogously, the para C-13 shift of the phenyl ring in PhNHAr (IV) is used as a monitor to evaluate, in terms of the previously defined ?C- constants, the blended polar-inductive and mesomeric effects exerted by such para-substituted aryl rings.The same para C-13 data offer access, through a biparametric (DSP) treatment, to ?R- constants, which account for the mesomeric effects exerted by the same substituents. C-13 Shift data are also reported for the 4'-substituted sodium aryl(phenyl)amides PhN-Ar (VII) which have been prepared in Me2SO by deprotonation of PhNHAr.The ?C- values just obtained account successfully for the para C-13 shifts of the phenyl ring of (VII), for the para C-13 shifts of the phenyl ring of phenylhydrazones of para-substituted benzaldehydes, and for the acidity of aryl(phenyl)amines measured in Me2SO-H2O by Dolman and Stewart.The success of the biparametric treatment is limited by the small range of the ?IB values of the para-substituted aryl derivatives and by the scarcity of data.The ?IB set is linearly related to the set of ?I constants obtained from substituted acetic acids.Both the ?IB and the ?C- sets account successfully for the acidity of para-substituted benzoic acids in H2O, in Me2SO, and in the gas phase: a rationale is given.
EFFECT OF THE STRUCTURE OF THE LEAVING GROUP, MEDIUM, AND TEMPERATURE ON THE ALKALINE HYDROLYSIS OF PHENYL BENZOATES IN WATER-DIOXANE MIXTURES
Sukhoruchkov, Yu. I.,Polonov, V. M.,Finkel'shtein, B. L.,Istomin, B. I.
, p. 1014 - 1019 (2007/10/02)
A spectrophotometric study was carried out on the kinetics of the alkaline hydrolysis of a series of para-substituted phenyl benzoates PhCO2C6H4X-p in water, 30 and 70 vol. percent aqueous dioxane at 15 deg, 25 deg, and 55 deg C.The bimolecular rate constants depend on the medium composition, temperature, and structure of the leaving group.It is of value to apply linear free energy (LFE) principles in studying these factors, which permits description of the entire set of experimental data by a single multidimensional regression equation.The Arrhenius equation parameters were calculated and this reaction series was shown to be compensated, in contrast to the alkaline hydrolysis of phenyl acetates.The dependence of the ρ constants in the Hammett-Taft equation on the medium composition and temperature indicate that this value is not a linear function of the extent of formation and breakage of bonds in the transition state.
