70031-68-4

Upstream product

• 31737-18-5 2-(4-quinazolinylthio)acetophenone 
• 1148122-18-2 2-(2-nitrophenyl)-4-phenylthiazole 
• 75221-01-1 2-(4-Phenyl-thiazol-2-yl)-phenylamine; compound with perchloric acid 

Downstream Products

• 75221-01-1 2-(4-Phenyl-thiazol-2-yl)-phenylamine; compound with perchloric acid 
• 1248340-74-0 1-[4-(trifluoromethyl)phenyl]-3-(2-(4-phenylthiazol-2-yl)phenyl)urea 
• 1262984-59-7 C₂₂H₁₈N₂O₂S₂ 

Relevant academic research and scientific papers

Thiazole-based chemosensor III: Synthesis and fluorescence sensing of CH3CO2- based on inhibition of ESIPT

Novel fluorogenic sensors based on urea derivative of 2-(2′- aminophenyl)-4-phenylthiazole (4 and 5) were prepared and used for recognition of anions with similar basicity and surface charge density. Chemosensor 4 was found to be highly selective to aceta

Thiazole sulfonamide based ratiometric fluorescent chemosensor with a large spectral shift for zinc sensing

A new thiazole sulfonamide (TTP, 1) based Zn2+ selective intrinsic chemosensor has been synthesized and investigated. The chemosensor shows a selective fluorescence enhancement (3.0 fold) with Zn2+ over biologically relevant cations (Ca2+, Mg2+, Na+, and K+) and biologically non-relevant cations (Cd2+) in an aqueous ethanol system. It produces an increase in the quantum yield and a longer emission wavelength shift (64 nm) on Zn2+ binding with the potential of a ratiometric assay.

AMIDE DERIVATIVES AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

HETEROCYCLES IN ORGANIC SYNTHESIS. PART V. A SYNTHESIS OF 2,5-DIARYL-1,4-DITHIINS

ω-(2-Methyl-4-quinazolinylthio or 2,6-dimethyl-4-pyrimidinylthio or 4-oxo-2-quinazolinylthio)acetophenones on treatment with hydrochloric or perchloric acid provide 2,5-diaryl-1,4-dithiins.

N-Quaternary Heterocyclics : Part X- Acid-catalysed Transformation of 2-(4-Quinazolinylthio)ketones to 2-ketones and 2-(o-Aminophenyl)thiazoles

2-(4-Quinazolinylthio)acetophenones (IV) when treated with a small amount of conc. sulphuric acid at room temperature or polyphosphoric acid at 130-40 deg C undergo sulphur extrusion and in the presence of perchloric acid afford 4-phenacylquinazolinium perchlorates (V).However, with an excess of conc.H2SO4, 3-arylthiazoloquinazolinium perchlorates (I), are also formed.Compounds (IV) on heating with perchloric or hydrochloric acid furnish 2-(o-aminophenyl)thiazoles (II) in synthetically useful yields.