700372-68-5

Basic information

• Product Name: Z-Leu-Leu-Leu-[methyl (3RS,4RS)-3,4-epoxypiperidine-3-carboxylate]
• CAS NO: 700372-68-5
• Molecular Weight: 630.782
• Mol File: 700372-68-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Z-Leu-Leu-Leu-[methyl (3RS,4RS)-3,4-epoxypiperidine-3-carboxylate](CAS DataBase Reference)
• NIST Chemistry Reference: Z-Leu-Leu-Leu-[methyl (3RS,4RS)-3,4-epoxypiperidine-3-carboxylate](700372-68-5)
• EPA Substance Registry System: Z-Leu-Leu-Leu-[methyl (3RS,4RS)-3,4-epoxypiperidine-3-carboxylate](700372-68-5)

Safety Data

• Hazardous Substances Data: 700372-68-5(Hazardous Substances Data)

Upstream product

• 134575-42-1 methyl 1-benzyloxycarbonyl-1,2,5,6-tetrahydropyridine-3-carboxylate 
• 3303-31-9 L-leucyl-L-leucine 
• 61-90-5 L-leucine 
• 3397-35-1 Z-L-leucine hydroxysuccinimide ester 
• 63-75-2 arecoline 
• 495-19-2 norarecoline 
• 18867-97-5 carbobenzoxy-L-leucyl-L-leucyl-L-leucine 
• 7801-71-0 N-benzyloxycarbonyl-L-leucyl-L-leucine 

Relevant articles and documents

Proteasome inhibitors: Synthesis and activity of arecoline oxide tripeptide derivatives

We describe the synthesis and biological activities of a series of methyl 3,4-epoxypiperidine-3-carboxylate tripeptide derivatives that inhibit the chymotryptic and tryptic active sites of the 20S proteasome. Of the series, compound 2 which contains 3-hydroxy-2-methylbenzoyl group at its N-terminal position, displayed the greatest inhibitory potency (IC50 1 μM). All derivatives showed favourable pharmacokinetic properties.