700374-01-2Relevant academic research and scientific papers
Parallel synthesis of DAPT derivatives and their γ-secretase- inhibitory activity
Kan, Toshiyuki,Tominari, Yusuke,Rikimaru, Kentaro,Morohashi, Yuichi,Natsugari, Hideaki,Tomita, Taisuke,Iwatsubo, Takeshi,Fukuyama, Tohru
, p. 1983 - 1985 (2004)
Parallel synthesis of the C-terminal-modified DAPT (1) derivatives was accomplished utilizing our novel resin 7. Condensation reaction of the N-acylamino acid 10 with the amines 11a-o proceeded smoothly to give the corresponding amides 6a-o without any epimerization. Among the analogues, the benzophenonemethyl amide derivative 6o showed 30 times more potent activity than the original DAPT (1).
