70039-17-7Relevant academic research and scientific papers
Solvent-free microwave synthesis 4 - phenyl methylene - 2, 6 - di-tert-butyl - 2, 5 - cyclohexadiene -1 - ketone (by machine translation)
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Paragraph 0054-0056, (2019/04/30)
The invention discloses a 4 - benzylidene - 2, 6 - di-tert-butyl - 2, 5 - cyclohexadiene - 1 - ketone derivative (P -QM) green preparation method. Under the condition of using solvent-free microwave radiation heating, 2, 6 - di-tert-butyl phenol and aldehyde, through the Mannich condensation and [...] two-step reaction, to obtain the 4 - benzylidene - 2, 6 - di-tert-butyl - 2, 5 - cyclohexadiene - 1 - ketone derivative (P -QM). This method has the raw material is cheap, the atom economy is high, fast reaction time, environment friendly, without the use of hazardous reagent and solvent, synthetic step is simple and convenient and the like, and the mild reaction conditions, substrate range wide applicability, simple and safe operation, and is suitable for industrial production. (by machine translation)
Unravelling the Nucleophilicity of Butenolides for 1,6-Conjugate Addition to p-Quinone Methides: A Direct Access to Diversely Substituted Butenolide-Derived Diarylmethanes
Sharma, Brijesh M.,Shinde, Dinesh R.,Jain, Ruchi,Begari, Eeshwaraiah,Satbhaiya, Shruti,Gonnade, Rajesh G.,Kumar, Pradeep
supporting information, p. 2787 - 2791 (2018/05/17)
A Lewis acid catalyzed regioselective C-C bond is constructed through β-addition of deconjugated butenolides with p-quinone methides in a 1,6-conjugate addition manner. Interestingly, Lewis acid catalyzed vinylogous Mukaiyama-Michael reaction of silyloxyfurans with p-QMs proceeds selectively through the α or γ position exclusively. The reaction is mild with broad substrate scope, thus allowing easy access to a wide range of bis-arylated α-/β-/γ-substituted butenolides.
Silver-Catalyzed Cascade 1,6-Addition/Cyclization of para-Quinone Methides with Propargyl Malonates: An Approach to Spiro[4.5]deca-6,9-dien-8-ones
Yuan, Zhenbo,Liu, Lina,Pan, Rui,Yao, Hequan,Lin, Aijun
, p. 8743 - 8751 (2017/08/23)
An unprecedented silver-catalyzed cascade 1,6-addition/5-exo-dig cyclization reaction between para-quinone methides and propargyl malonates under mild reaction conditions has been described. This reaction provides an efficient method to construct versatile spiro[4.5]cyclohexadienones in moderate to excellent yields with high atom economy and scalability.
Copper-Catalyzed 1,6-Hydrodifluoroacetylation of para-Quinone Methides at Ambient Temperature with Bis(pinacolato)diboron as Reductant
Ke, Miaolin,Song, Qiuling
, p. 384 - 389 (2017/02/10)
An original and efficient copper-catalyzed 1,6-hydrodifluoroacetylation of para-quinone methides with difluoroalkyl bromides has been described with bis(pinacolato)diboron (B2pin2) as reductant. In this reaction, a new C(sp3)–CF2bond is constructed under smart conditions. A broad substrate scope of para-quinone methides (p-QMs) make this protocol very practical and attractive. Preliminary mechanistic studies manifested that a difluoroalkyl radical pathway was involved in this reaction. Also the presence of the diboron reagent was an essential requisite in this transformation. (Figure presented.).
