70052-55-0

Usage

Uses

Used in Organic Synthesis:
2-Propyn-1-amine, 3-(trimethylsilyl)is used as a reagent in organic synthesis for the introduction of an amino group into other molecules. Its propynyl and trimethylsilyl groups provide opportunities for further functionalization and modification, making it a valuable intermediate in the synthesis of various organic compounds.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2-Propyn-1-amine, 3-(trimethylsilyl)is utilized in the development of new drugs and active pharmaceutical ingredients. Its unique structure allows for the creation of novel molecular entities with potential therapeutic properties. 2-Propyn-1-amine, 3-(trimethylsilyl)-'s reactivity and functional groups can be exploited to design and synthesize drug candidates with improved pharmacokinetic and pharmacodynamic profiles.
Used in the Production of Functionalized Organic Compounds:
2-Propyn-1-amine, 3-(trimethylsilyl)is employed in the synthesis of a wide range of functionalized organic compounds, including heterocyclic compounds with biological activity. Its propynyl and trimethylsilyl groups can be used to construct complex molecular architectures with diverse applications in materials science, agrochemistry, and other fields.
Used in the Synthesis of Heterocyclic Compounds:
2-Propyn-1-amine, 3-(trimethylsilyl)has been studied for its potential use in the synthesis of heterocyclic compounds with biological activity. 2-Propyn-1-amine, 3-(trimethylsilyl)-'s unique structure and reactivity make it a promising candidate for the development of new heterocyclic scaffolds with potential applications in medicinal chemistry and drug discovery. The synthesis of these heterocyclic compounds can lead to the discovery of new bioactive molecules with therapeutic potential.

Upstream product

• 351029-12-4 N-[3'-(trimethylsilyl)prop-2'-ynyl]phthalimide 
• 1365478-22-3 (3-azidoprop-1-ynyl)trimethylsilane 
• 71321-17-0 methanesulfonic acid 3-trimethylsilyl-propyn-2-ynyl ester 
• 5272-36-6 3-trimethylsilyl-2-propyn-1-ol 
• 91375-26-7 1-(N,N-bis(trimethylsilyl)amino)-3-trimethylsilylprop-2-yne 

Downstream Products

• 1365478-26-7 (1R,3R,4R,5S)-3-[2-O-benzoyl-3-O-((1S)-1-carboxy-2-cyclohexylethyl)-(β-D-galactopyranosyl)oxy]-4-[(α-L-fucopyranosyl)oxy]-5-methyl-N-[3-(trimethylsilyl)prop-2-yn-1-yl]cyclohexanecarboxamide 
• 333332-93-7 4-Methyl-benzenesulfinic acid (S)-(2-methyl-allyl)-(3-trimethylsilanyl-prop-2-ynyl)-amide 
• 333332-83-5 4-methyl-benzenesulfinic acid (3-trimethylsilanyl-prop-2-ynyl)-amide 

Relevant academic research and scientific papers

Nanomolar e-selectin antagonists with prolonged half-lives by a fragment-based approach

Selectins, a family of C-type lectins, play a key role in inflammatory diseases (e.g., asthma and arthritis). However, the only millimolar affinity of sialyl Lewisx (sLex), which is the common tetrasaccharide epitope of all physiological selectin ligands, has been a major obstacle to the development of selectin antagonists for therapeutic applications. In a fragment-based approach guided by NMR, ligands binding to a second site in close proximity to a sLex mimic were identified. A library of antagonists obtained by connecting the sLex mimic to the best second-site ligand via triazole linkers of different lengths was evaluated by surface plasmon resonance. Detailed analysis of the five most promising candidates revealed antagonists with KD values ranging from 30 to 89 nM. In contrast to carbohydrate-lectin complexes with typical half-lives (t1/2) in the range of one second or even less, these fragment-based selectin antagonists show t1/2 of several minutes. They exhibit a promising starting point for the development of novel anti-inflammatory drugs.

E-SELECTIN ANTAGONISTS

Compounds, compositions and methods are provided for inhibiting in vitro and in vivo processes mediated by E-selectin binding. More specifically, particular glycomimetic compounds are described, wherein the compounds are E- selectin antagonists.

Design and photophysical properties of zinc(II) porphyrin-containing dendrons linked to a central artificial special pair

The click chemistry synthesis and photophysical properties, notably photo-induced energy and electron transfers between the central core and the peripheral chromophores of a series of artificial special pair-dendron systems (dendron=G1, G2, G3; Gx=zinc(II) tetra-meso-arylporphyrin-containing polyimides) built upon a central core of dimethylxanthenebis(metal(II) porphyrin) (metal=zinc, copper), are reported. The dendrons act as singlet and triplet energy acceptors or donors, depending on the dendrimeric systems. The presence of the paramagnetic d9 copper(II) in the dendrimers promotes singlet-triplet energy transfer from the zinc(II) tetra-meso-arylporphyrin to the bis(copper(II) porphyrin) unit and slow triplet-triplet energy transfer from the central bis(copper(II) porphyrin) fragment to the peripheral zinc(II) tetra-meso-arylporphyrin. If bis(zinc(II) porphyrin) is the central core, evidence for chain folding is observed; this is unambiguously demonstrated by the presence of triplet-triplet energy transfer in the heterobimetallic systems, a process that can only occur at short distances.

Electron Delocalisation and Stabilisation in Substituted Amino- and Hydroxypropynyl Radicals

A series of aminopropynes, RCCCH2NH2 (R = H, Me, t-Bu, Me3Si), RCCCH2N(SiMe3)2, and hydroxypropynes RCCCH2OH (R = H, Me, t-Bu, Me3Si, CF3, and EtO2C), were prepared and the corresponding α-aminopropynyl and α-hydroxypropynyl radicals were examined by e.s.r. spectroscopy.For the first series, the C-N bond rotation barriers were determined from the exchange broadening in the spectra and hence radical stabilization energies were estimated.The spin distribution in these series indicated an extra delocalisation in radicals with captodative substitution.

Acetylene derivatives

Novel compounds of the following general formula are useful pharmacologic agents and are useful as intermediates for the preparation of pharmacologically useful compounds. STR1 wherein R1 is a straight or branched lower alkyl group having from 1 to 4 carbon atoms, R2 is trialkylmethyl, phenyl, 1-adamantanyl or 2-furyl; R3 is methoxy or ethoxy; and acid addition salts thereof.