70057-67-9

Usage

Uses

Used in Pharmaceutical Industry:
5-(3-CHLORO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE is used as a potential pharmaceutical agent for its unique chemical structure, which may contribute to the development of new drugs with specific therapeutic effects. Its properties could be harnessed to target various medical conditions, pending further research and clinical trials.
Used in Agricultural Industry:
In agriculture, 5-(3-CHLORO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE may be utilized as a component in the development of agrochemicals, such as pesticides or herbicides, due to its chemical properties that could influence plant pests or weeds.
Used in Materials Science:
5-(3-CHLORO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE is used in materials science for its potential to contribute to the creation of novel materials with specific properties. Its unique structure could be key in developing advanced materials for various applications, including but not limited to electronics, coatings, or composites.

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 79-19-6 thiosemicarbazide 
• 618-46-2 m-Chlorobenzoyl chloride 
• 535-80-8 3-chlorobenzoate 
• 587-04-2 m-Chlorobenzaldehyde 
• 881-74-3 2-(3-chlorobenzoyl)hydrazinecarbothioamide 
• 5706-79-6 (3-chlorobenzylidenehydrazinyl)thiocarboxamide 

Downstream Products

• 125161-12-8 2-(m-chlorophenyl)-6-(p-phenylphenyl)imidazo<2,1-b>-1,3,4-thiadiazole 
• 73653-65-3 2-(m-chlorophenyl)-6-phenylimidazo<2,1-b>-1,3,4-thiadiazole 
• 125161-11-7 2-(m-chlorophenyl)-6-(p-tolyl)imidazo<2,1-b>-1,3,4-thiadiazole 
• 125161-15-1 2-(m-chlorophenyl)-6-(p-chlorophenyl)imidazo<2,1-b>-1,3,4-thiadiazole 
• 125161-10-6 2-(m-chlorophenyl)-6-(p-bromophenyl)imidazo<2,1-b>-1,3,4-thiadiazole 
• 91660-25-2 2-Chloro-5-(3-chloro-phenyl)-[1,3,4]thiadiazole 
• 1338084-32-4 C₁₈H₁₇ClN₆O₃S 
• 1338083-77-4 C₁₃H₉ClN₆O₂S 
• 1338084-11-9 C₁₃H₈ClN₅O₂S 
• 1338083-99-0 C₁₅H₁₂ClN₅O₂S 
• 1369885-74-4 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(3-chlorophenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide 

Relevant academic research and scientific papers

Design, synthesis and insecticidal activity of new 1,3,4-thiadiazole and 1,3,4-thiadiazolo[3,2-a]pyrimidine derivatives under solvent-free conditions

5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine 2 was synthesized and employed to synthesize new 1,3,4-thiadiazole and 1,3,4-thiadiazolo[3,2-a]pyrimidine derivatives via reactions with variant electrophilic reagents under solvent-free conditions. The chemical structures of these novel compounds were elucidated scrupulously by aiding elemental data and spectroscopic techniques. The synthesized compounds were evaluated for the insecticidal activity against cotton leaf worm (Spodoptera littoralis). It was realized that the insecticidal activity of 1,3,4-thiadiazolo[3,2-a]pyrimidine derivatives emerged remarkable results comparable with 1,3,4-thiadiazole derivatives against cotton leafworm (Spodoptera littoralis).

N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound

The invention belongs to the technical field of medicines, relates to a compound with antitumor activity and a specific chemical structure, and in particular relates to an N-((6, 7-dimethoxyquinoline-4-yl) oxy) methyl)-N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound and a preparation method and an application thereof. The structural general formula of the compound is shown in the specification, wherein an R group is mono-substituted or double-substituted phenyl, fluorophenyl, chlorphenyl, bromophenyl, benzyl, benzyloxy, benzene nitro or trifluoromethyl substituted at 2-position, 3-position or 4-position. Pharmacological studies show that the compound provided by the invention has a relatively remarkable proliferation inhibition effect on HER-2 positive breast cancer cells SK-Br-3, the effect is obviously superior to that of HER-2 negative breast cancer cells MCF-7, the compound can be used for preparing antitumor drugs, and a new way is opened up for deep research and development of tumor drugs in the future. The preparation method provided by the invention is simple and feasible, relatively high in yield and easy for large-scale production.

Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.

Synthesis of indole-tethered [1,3,4]thiadiazolo and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids as anti-pancreatic cancer agents

New indole-tethered [1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one (8a-j) and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids (9a-e) were synthesized using [4+2] cycloaddition reactions of functionalized 1,3-diazabuta-1,3-dienes with indole-ketenes. All molecul

Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies

A series of 15 novel 1,3,4-thiadiazole amide derivatives containing a protocatechuic acid moiety were synthesized and structurally characterized. In addition, the corresponding imino (4) and amino (5) analogues of a phenyl-substituted 1,3,4-thiadiazole am

PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles

A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.

Synthesis and molecular simulation study of furoic peptidomimetic derivatives as potent aminopeptodase N inhibitors

The aminopeptidase N (APN) plays a critical role in angiogenesis and is over-expressed in tumor cells. In this paper, we report the synthesis and enzyme inhibition assay of furoic peptidomimetic compounds. These new compounds exhibit potent inhibitory ability toward APN with IC50 values lying in the micromolar level. The binding mode of inhibitors in APN active site was explained by a molecular simulation study. These data reveal that ligand coordinating with the catalytic Zn-ion is very important for inhibitory activities.

Synthesis of matrinic amide derivatives containing 1,3,4-thiadiazole scaffold as insecticidal/acaricidal agents

In continuation of our program aimed at the development of natural product-based pesticidal agents, a series of matrinic amide derivatives containing 1,3,4-thiadiazole scaffold were prepared, and their insecticidal and acaricidal activities were evaluated against Mythimna separata and Tetranychus cinnabarinus. Some compounds exhibited potent insecticidal and acaricidal activities. It suggested that R1 as a nitro group and R2 as a fluorine atom, were important for the insecticidal activity; R1 as the electron-donating groups and R2 as the methyl group, were necessary for the acaricidal activity.

Synthesis, characterization and biological evaluation of some novel fluoroquinolones

Different derivatives of fluoroquinolones were synthesized by combining it with different thiadiazoles. The synthesized compounds were characterized by infrared spectroscopy, proton nuclear magnetic resonance and mass spectral data. The compounds were screened for their antibacterial and antifungal activity. Ciprofloxacin derivatives with thiadiazoles 7c showed good antibacterial as well as antifungal activities, whereas 13c and 13e showed antibacterial and antifungal activity respectively. Sparfloxacin derivative 8c showed both antibacterial and antifungal activity. Sparfloxacin derivatives 14b and 14e showed antibacterial and antifungal activity respectively.