70070-23-4

Downstream Products

• 117844-54-9 1-phenyl-3-(5'-chloro-3'-methyl-indole-2'-carboxamido)-thiourea 
• 120607-59-2 5-Chloro-3-methyl-1H-indole-2-carboxylic acid [1-phenyl-eth-(E)-ylidene]-hydrazide 
• 126016-09-9 5-(5-chloro-3-methyl-1H-indol-2-yl)-N-phenyl-1,3,4-oxadiazol-2-amine 
• 126016-23-7 5-chloro-3-methyl-2-(5'-phenylamino-1',3',4'-thiadiazol-2'-yl)indole 
• 126016-37-3 5-chloro-3-methyl-2-(5'-mercapto-4'-phenyl-1',2',4'-triazol-3'-yl)indole 
• 117844-64-1 3-(5'-chloro-3'-methyl-indole-2'-carboxamido)-2-phenylimino-4-thiazolidinone 
• 120607-66-1 1-(5-Chloro-3-methyl-1H-indole-2-carbonyl)-3-phenyl-1H-pyrazole-4-carbaldehyde 
• 117844-60-7 5-Chloro-3-methyl-1H-indole-2-carboxylic acid (4,6-dioxo-3-phenyl-2-thioxo-tetrahydro-pyrimidin-1-yl)-amide 
• 457891-69-9 5-chloro-3-methyl-indole-2-carboxylic acid (4-methylbenzylidene)-hydrazide 
• 457891-72-4 5-Chloro-3-methyl-indole-2-carboxylic acid (3-methylbenzylidene)-hydrazide 

Relevant academic research and scientific papers

Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs thereof, represented by the general Formula I: wherein X, Ar1, R2-R6 and R12 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.