70074-31-6

Basic information

• Product Name: SHB
• Synonyms: SUCCINIMIDYL-4-HYDROXYBENZOATE;SHB
• CAS NO: 70074-31-6
• Molecular Formula: C₁₁H₉NO₅
• Molecular Weight: 235.19
• Product Categories: iodination
• Mol File: 70074-31-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 175-176°C
• Appearance: /
• CAS DataBase Reference: SHB(CAS DataBase Reference)
• NIST Chemistry Reference: SHB(70074-31-6)
• EPA Substance Registry System: SHB(70074-31-6)

Safety Data

• Hazardous Substances Data: 70074-31-6(Hazardous Substances Data)

Usage

General Description

Succinimidyl-4-hydroxybenzoate, also known as S-4-HB, is a chemical compound often used in biological and chemical studies. It is renowned for its reactivity and efficiency as it can readily form stable amide bonds with amines. This capability has deemed it valuable in the fields of bioconjugation and protein labeling, as it can be utilized to attach various probes or molecules to proteins. Succinimidyl-4-hydroxybenzoate is typically stored at -20°C and is moisture sensitive, needing careful handling. Despite its wide usage in research and development, extensive health effects and toxicity information are relatively limited.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 99-96-7 4-hydroxy-benzoic acid 
• 17592-54-0 2,5-dioxopyrrolidin-1-yl formate 
• 540-38-5 p-Iodophenol 
• 28141-24-4 4-hydroxybenzoyl chloride 

Downstream Products

• 548765-45-3 4-(methyl-phenyl-carbamoyloxy)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 1034015-46-7 dibenzoyloxysuccinimidyl ethyl phosphate 
• 1345822-30-1 5-(4-hydroxybenzoylaminomethyl)-2'-deoxyuridine triphosphate 

Relevant articles and documents

Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N-Hydroxysuccinimidyl Formate as CO Surrogate

An efficient Pd-catalyzed carbonylation protocol is described for the coupling of a large panel of aryl, heteroaryl, benzyl, vinyl and allyl halides 2 with the unusual N-hydroxysuccinimidyl (NHS) formate 1 as a CO surrogate to afford the corresponding valuable NHS esters 3. High conversion to the coupling products was achieved with up to 98% yield by means of Pd(OAc)2/Xantphos catalyst system.

Chromogenic cross-linker for the characterization of protein structure by infrared multiphoton dissociation mass spectrometry

We have developed a new IR chromogenic cross-linker (IRCX) to aid in rapidly distinguishing cross-linked peptides from unmodified species in complex mixtures. By incorporating a phosphate functional group into the cross-linker, one can take advantage of i

SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE OF SENSITIVE LIPASE

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