70076-42-5

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 555-68-0 (E)-3-Nitrocinnamic acid 
• 6148-64-7 ethyl potassium malonate 
• 623-73-4 diazoacetic acid ethyl ester 
• 1504-76-3 (E)-3-nitrocinnamaldehyde 

Downstream Products

• 116904-38-2 ethyl 4-<(E)-2-(3-nitrophenyl)ethenyl>-2-phenyl-5-pyrimidinecarboxylate 
• 39562-70-4 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester 
• 39562-23-7 2,6-dimethyl-4-(3'-nitrophenyl)1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-allyl ester 
• 39562-24-8 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-propargyl ester 
• 116904-40-6 4-<(E)-2-(3-nitrophenyl)ethenyl>-2-phenyl-5-pyrimidinecarboxylic acid 
• 1025875-80-2 4-[(E)-2-(3-Nitro-phenyl)-vinyl]-2-phenyl-pyrimidine-5-carbonyl chloride 

Relevant academic research and scientific papers

Preparation of γ,δ-unsaturated-β-ketoesters: Lewis acid-catalysed C[sbnd]H insertion of ethyl diazoacetate into α,β-unsaturated aldehydes

The synthesis of γ,δ-unsaturated-β-keto esters was achieved by the Lewis acid-catalysed direct C[sbnd]H insertion of an α-diazoester into various α,β-substituted-unsaturated aldehydes. C[sbnd]H insertion of ethyl diazoacetate into alkyl- and aryl-substituted α,β-unsaturated aldehydes was performed under mild conditions to afford the corresponding γ,δ-unsaturated-β-keto esters in moderate to high yields as a mixture of keto/enol tautomers.

Benzoxazepinones and their use as squalene synthase inhibitors

There is disclosed a compound represented by the formula [I]: wherein R1 is optionally substituted 1-carboxyethyl group, optionally substituted alkyl-sulfonyl group, optionally substituted (carboxy-cycloalkyl)-alkyl group, -X1-X2-Ar-X3-X4-COOH (wherein X1 and X4 are a bond or alkylene group, X2 and X3 are a bond, -O-, -S-, Ar is divalent aromatic group etc.), R2 is alkyl group optionally substituted with alkanoyloxy group and/or hydroxy group, R3 is alkyl group, and W is halogen atom, etc., or a salt thereof. The compound has the cholesterol lowering activity and the triglyceride lowering activity and is useful for preventing and/or treating hyperlipidemia.

Studies on cerebral protective agents. VI. Synthesis of novel 4-(4- nitrobenzoyl)pyrimidine and related compounds with anti-anoxic activity

Novel pyrimidine derivatives, possessing linkages between the aryl group and the pyrimidine nucleus at the C-4 position, were prepared and tested for anti-anoxic (AA) activity in mice. Among them, 5-(4-methylpiperazin-1- ylcarbonyl)-4-(4-nitrobenzoyl)-2-p