700805-03-4Relevant academic research and scientific papers
NOVEL SUBSTITUTED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
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Page/Page column 24, (2012/12/13)
The present invention is concerned with novel substituted triazole derivatives of Formula (I) wherein Het1, R1, R2, A1, A2, A3, A4, L1, and L2 have the mean
NOVEL SUBSTITUTED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
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Page/Page column 53-54, (2011/08/04)
The present invention is concerned with novel substituted triazole derivatives of Formula (I) wherein Het1, R1, R2, A1, A2, A3, A4, L1, and L2 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma sec
Design, synthesis, and evaluation of a novel dual fms-like tyrosine kinase 3/stem cell factor receptor (FLT3/c-KIT) inhibitor for the treatment of acute myelogenous leukemia
Davies, Robert J.,Pierce, Albert C.,Forster, Cornelia,Grey, Ron,Xu, Jinwang,Arnost, Michael,Choquette, Deborah,Galullo, Vincent,Tian, Shi-Kai,Henkel, Greg,Chen, Guanjing,Heidary, David K.,Ma, Joanne,Stuver-Moody, Cameron,Namchuk, Mark
supporting information; experimental part, p. 7184 - 7192 (2011/12/03)
A high-throughput screen of our compound archive revealed a novel class of dual FMS-like tyrosine kinase 3 (FLT3)/c-KIT inhibitors. With the help of molecular modeling, this class was rapidly optimized for both potency against FLT3 and FLT3/c-KIT and exce
