700805-33-0Relevant academic research and scientific papers
Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3
Malerich, Jeremiah P.,Lam, Jennifer S.,Hart, Barry,Fine, Richard M.,Klebansky, Boris,Tanga, Mary J.,D'Andrea, Annalisa
scheme or table, p. 7454 - 7457 (2011/01/12)
Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1-3.
