700845-07-4Relevant academic research and scientific papers
Inhibition of Src kinase activity by 7-[(2,4-dichloro-5-methoxyphenyl) amino]-2-heteroaryl-thieno[3,2-b]pyridine-6-carbonitriles
Boschelli, Diane H.,Wu, Biqi,Barrios Sosa, Ana Carolina,Chen, Joan J.,Golas, Jennifer M.,Boschelli, Frank
, p. 4681 - 4684 (2005)
7-[(2,4-Dichloro-5-methoxyphenyl)amino]thieno[3,2-b]pyridine-6- carbonitriles with various heteroaryl groups at C-2 are inhibitors of Src kinase activity. Of these new analogs, compounds substituted at C-2 by a 3,5-furan or a 2,5-pyridine had the best activity in the Src enzyme and cell assays.
Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
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, (2008/06/13)
This invention provides compounds of Formula (1a)-(1f), II wherein: X, m, n, q, R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Q, Z, Z′, Z′″, Z″ and J are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.
THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS
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Page 133, (2010/02/07)
This invention provides compounds of Formula (1 a) - (1f) wherein:X, R1, and R2 are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.
