700847-04-7Relevant articles and documents
Vancomycin dimer formation between analogues of bacterial peptidoglycan surfaces probed by force spectroscopy
Batchelor, Matthew,Zhou, Dejian,Cooper, Matthew A.,Abell, Chris,Rayment, Trevor
supporting information; experimental part, p. 1142 - 1148 (2010/06/15)
Functionalised thiols presenting peptides found in the peptidoglycan of vancomycin-sensitive and -resistant bacteria were synthesised and used to form self-assembled monolayers (SAMs) on gold surfaces. This model bacterial cell-wall surface mimic was used to study binding interactions with vancomycin. Force spectroscopy, using the atomic force microscope (AFM), was used to investigate the specific rupture of interfacial vancomycin dimer complexes formed between pairs of vancomycin molecules bound to peptide-coated AFM probe and substrate surfaces. Clear adhesive contacts were observed between the vancomycin-sensitive peptide surfaces when vancomycin was present in solution, and the adhesion force demonstrated a clear dependence on antibiotic concentration. The Royal Society of Chemistry.
Synthesis of a photo-caged aminooxy alkane thiol
Mancini, Rock J.,Li, Ronald C.,Tolstyka, Zachary P.,Maynard, Heather D.
experimental part, p. 4954 - 4959 (2010/02/16)
A photo-caged aminooxy alkane thiol synthesized in 7 steps and 15% overall yield was used to form a self-assembled monolayer (SAM). Photo-deprotection on the surface was confirmed by FT-IR spectroscopy and contact angle goniometry. Conjugation of a small molecule ketone, ethyl levulinate, further confirmed the presence of aminooxy groups on the surface. The Royal Society of Chemistry 2009.
