700867-66-9Relevant academic research and scientific papers
Carbamoylphosphonate MMP inhibitors. Part 4: The influence of chirality and geometrical isomerism on the potency and selectivity of inhibition
Breuer, Eli,Katz, Yiffat,Hadar, Rivka,Reich, Reuven
, p. 2415 - 2420 (2004)
Matrix metalloproteinases (MMPs) are a family of over twenty zinc-dependent enzymes that hydrolyze connective tissue and are involved in a variety of diseases, which are associated with undesired tissue breakdown. Previously we described the synthesis of
NEW CARBAMOYL-AND THIOCARBAMOYL-PHOSPHONATES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
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Page 15, (2010/02/09)
The present invention provides a compound of the following formula (I): R3-NH-C(=X)-P(=O)OR1OR2including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geo
