700875-87-2Relevant academic research and scientific papers
Synthesis and characterization of new chiral azolinium salts, precursors to N-heterocyclic carbenes, derived from l-proline
Thomasset, Amélia,Bouchardy, Lucie,Bournaud, Chloée,Guillot, Régis,Toffano, Martial,Vo-Thanh, Giang
, p. 242 - 250 (2014/03/21)
A short and flexible procedure for the preparation of seven chiral azolinium and five functionalized chiral azolinium salts, precursors to N-heterocyclic carbenes, derived from l-proline has been developed. Moderate to good overall yields were obtained. Some NHC dimers and thiones were isolated. X-ray crystal structure determinations of two [Rh-NHC] complexes were also reported.
Asymmetric conjugate addition of ketones to β-nitrostyrenes by means of 1,2-amino-alcohol-derived prolinamides as bifunctional catalysts
Almasi, Diana,Alonso, Diego A.,Gomez-Bengoa, Enrique,Nagel, Yvonne,Najera, Carmen
, p. 2328 - 2343 (2008/02/08)
Different L-prolinamides 21, prepared from L-proline and chiral β-amino alcohols are active bifunctional catalysts for the direct nitro-Michael addition of ketones to β-nitrostyrenes. In particular, catalyst 21e, prepared from L-proline and (1S,2R?)-cis-1
Enantioselective conjugate addition of ketones to β-nitrostyrenes catalyzed by 1,2-amino alcohol-derived prolinamides
Almasi, Diana,Alonso, Diego A.,Najera, Carmen
, p. 2064 - 2068 (2007/10/03)
Various l-prolinamides 14, prepared from l-proline and chiral β-amino alcohols, are active bifunctional catalysts for the direct nitro-Michael addition of ketones to β-nitrostyrenes. In particular, catalyst 14e prepared from l-proline and (1S,2R)-cis-1-am
Preparation of pyrrolidine-oxazoline containing ligands and their application in asymmetric transfer hydrogenation
McManus, Helen A.,Barry, Sarah M.,Andersson, Pher G.,Guiry, Patrick J.
, p. 3405 - 3416 (2007/10/03)
Nine members of a new ligand class incorporating both an oxazoline ring and a pyrrolidine unit were prepared in an efficient four-step synthesis starting from readily available chiral amino alcohols and proline. A study of these ligands in the asymmetric transfer hydrogenation of acetophenone showed that the catalysts formed from [Ir(cod)Cl]2 were the most active while those derived from [Ru(p-cymene)Cl2]2 gave the highest enantioselectivities (up to 61% ee).
