700875-92-9Relevant academic research and scientific papers
Preparation of pyrrolidine-oxazoline containing ligands and their application in asymmetric transfer hydrogenation
McManus, Helen A.,Barry, Sarah M.,Andersson, Pher G.,Guiry, Patrick J.
, p. 3405 - 3416 (2007/10/03)
Nine members of a new ligand class incorporating both an oxazoline ring and a pyrrolidine unit were prepared in an efficient four-step synthesis starting from readily available chiral amino alcohols and proline. A study of these ligands in the asymmetric transfer hydrogenation of acetophenone showed that the catalysts formed from [Ir(cod)Cl]2 were the most active while those derived from [Ru(p-cymene)Cl2]2 gave the highest enantioselectivities (up to 61% ee).
