70091-25-7Relevant academic research and scientific papers
Process for preparing N6,9-disubstituted adenine
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, (2008/06/13)
A process for preparing N6, 9-disubstituted adenines which comprises reacting a metal salt of N6 -substituted adenine with a benzyl halide compound, preferably in the presence of a phase transfer catalyst. According to the process, the N6,9-disubstuted adenines can be obtained in high yields and good selectivity.
SYNTHESIS OF N,N,9-TRISUBSTITUTED ADENINES UNDER CONDITIONS OF PHASE-TRANSFER CATALYSIS
Ramzaeva, N. P.,Gol'dberg, Yu. Sh.,Alksnis, E. R.,Lidak, M. Yu.,Shimanskaya, M. V.
, p. 1611 - 1615 (2007/10/02)
Alkylation of N-mono- and N,N-disubstituted adenines by 2,6-dichlorobenzyl chlorides under the conditions of phase-transfer catalysis in the benzene-50percent aqueous sodium hydroxide system takes place regioselectively with the formation of the corresponding N,N,9-trisubstituted adenines (60-80percent).The isomeric N,N,3-trisubstituted adenines are also formed.The N,9-disubstituted adenines are alkylated regiospecifically under analogous conditions and give N,N,9-trisubstituted adenines with quantitative yields.
Purine derivatives
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, (2008/06/13)
Novel purine derivatives of the formula: STR1 wherein R1 is hydrogen or alkyl of 1 to 3 carbon atoms, R2 is alkyl of 1 to 3 carbon atoms or allyl, and R3 and R4, respectively, mean halogen, and their acid additi
