70097-49-3

Basic information

• Product Name: 1(3H)-Isobenzofuranone,3-hydroxy-6-methoxy-(9CI)
• Synonyms: 1(3H)-Isobenzofuranone,3-hydroxy-6-methoxy-(9CI)
• CAS NO: 70097-49-3
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.15742
• Product Categories: PHENYL
• Mol File: 70097-49-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1(3H)-Isobenzofuranone,3-hydroxy-6-methoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1(3H)-Isobenzofuranone,3-hydroxy-6-methoxy-(9CI)(70097-49-3)
• EPA Substance Registry System: 1(3H)-Isobenzofuranone,3-hydroxy-6-methoxy-(9CI)(70097-49-3)

Safety Data

• Hazardous Substances Data: 70097-49-3(Hazardous Substances Data)

Upstream product

• 85370-63-4 N,N-diethyl-2-formyl-5-methoxybenzamide 
• 40125-47-1 3-Bromo-6-methoxy-3H-isobenzofuran-1-one 
• 68-12-2 N,N-dimethyl-formamide 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 4741-63-3 6-methoxyphthalide 
• 586-38-9 3-Methoxybenzoic acid 
• 85370-85-0 N,N-diethyl-3-methoxy-2-(trimethylsilyl)benzamide 
• 85370-76-9 N,N-diethyl-6-formyl-3-methoxy-2-(trimethylsilyl)benzamide 
• 62924-93-0 N,N-diethyl-3-methoxybenzamide 

Downstream Products

• 77620-05-4 methyl 5-methoxyl-2-formylbenzoate 

Relevant articles and documents

6-Benzyloxyphthalides as selective and reversible monoamine oxidase B inhibitors with antioxidant and anti-neuroinflammatory activities for Parkinson's disease treatment

A series of 6-benzyloxyphthalides were designed and synthesized as potent monoamine oxidase B inhibitors with antioxidant and anti-neuroinflammatory activities. The representative compounds 8f and 14a exhibited excellent selective MAO-B inhibition activity (IC50 = 1.33 nM, SI = 865; IC50 = 0.02 nM, SI = 40250, respectively) and moderate antioxidant activity (0.34 and 0.36 Trolox equivalent, respectively). Further studies showed that they were competitive and quasi-reversible MAO-B inhibitors. In cellular experiments, they could significantly decrease the production of NO and TNF-α in LPS-stimulated BV-2 cells to perform their in vitro anti-neuroinflammatory activities. Moreover, BBB permeability study and the predicted physicochemical properties indicated they were suitable for the CNS. Finally, in in vivo acute and subacute MPTP-induced mice model of PD, 8f and 14a could significantly improve most behavioral disorders, restore the DA content and decrease the MDA content in the mice striatum, exhibiting better anti-PD effects than clinically used safinamide. Hence, compounds 8f and 14a are identified in our studies as prospective prototype in the research of innovative multifunctional drugs for Parkinson's disease treatment.

Chiral Phosphoric Acid Catalyzed Asymmetric Ugi Reaction by Dynamic Kinetic Resolution of the Primary Multicomponent Adduct

Reaction of isonitriles with 3-(arylamino)isobenzofuran-1(3H)-ones in the presence of a catalytic amount of an octahydro (R)-binol-derived chiral phosphoric acid afforded 3-oxo-2-arylisoindoline-1-carboxamides in high yields with good to high enantioselec

Rational design of inhibitors of VirA-VirG two-component signal transduction

VirA-VirG two-component system regulates the vir (virulence) operon in response to specific host factors (xenognosins) in the plant pathogen Agrobacterium tumefaciens. Using whole cell assays, stable inhibitors inspired by the labile natural benzoxazinone inhibitor HDMBOA are developed. It is found that aromatic aldehydes represent a minimal structural unit for activity. In particular, 3-hydroxy-4,6-dimethoxy-3H-isobenzofuran-1-one (HDI) was found to have the highest activity, making it the most potent developed inhibitor of virulence gene expression in Agrobacterium.