701-14-4

Usage

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazol-2-amine,4-chloro-(9CI) is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure, including the benzimidazole ring and the chlorine atom, may provide specific biological activities or enhance the properties of the resulting pharmaceuticals, such as improving solubility, stability, or bioavailability.
Used in Agrochemical Industry:
In the agrochemical field, 1H-Benzimidazol-2-amine,4-chloro-(9CI) may be utilized as a building block for the development of new agrochemicals, such as pesticides or herbicides. Its chemical properties could contribute to the effectiveness of these products, potentially leading to improved crop protection and yield.
Used in Material Science:
1H-Benzimidazol-2-amine,4-chloro-(9CI) may also find applications in material science, where its unique structure could be employed to develop new materials with specific properties. For example, it could be used in the synthesis of advanced polymers, coatings, or other materials with tailored characteristics for various applications.

Upstream product

• 506-68-3 bromocyane 
• 21745-41-5 2,3-diaminochlorobenzene 

Relevant academic research and scientific papers

JAK-2 MODULATORS AND METHODS OF USE

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention

Method of inhibiting the advanced glycosylation of proteins using 1,2-disubstituted-benzimidazoles

The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, composition is disclosed which comprises 1,2-disubstituted benzimidazoles capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

Iminoisoindolinone metal complex

Iminoisoindolinone metal complexes of formula STR1 wherein A represents a 5- or 6-membered heterocyclic radical which contains at least one further heteroatom and can be fused or doubled with benzene nuclei, M represents a divalent metal atom excluding the alkaline earth metals, X represents a hydrogen atom, Y represents a halogen atom, Z represents a nitro group, an alkoxycarbonyl group of 2 to 6 carbon atoms or a group of formula RY2 --, wherein R represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms which is substituted by an aryl radical or is unsubstituted, a cycloalkyl group of 5 to 6 carbon atoms, or represents an aryl group, and Y2 represents an oxygen or a sulphur atom, m and n are 0 to 4, p is 0 to 2, and the sum of m+n+p must be 4, which are useful for pigmenting high molecular organic material.