701232-69-1 Usage
Description
2-[(1r,4r)-4-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclohexyl]acetate is a complex organic compound characterized by a cyclohexyl ring and a boron-containing phenyl group. It is an acetate derivative, featuring an acetate functional group, and also contains a dioxaborolane ring and multiple methyl groups. This unique structure and the presence of various functional groups suggest potential applications in organic synthesis, pharmaceuticals, and agrochemicals.
Uses
Used in Organic Synthesis:
2-[(1r,4r)-4-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclohexyl]acetate is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure and functional groups make it a valuable component in the synthesis of new compounds.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2-[(1r,4r)-4-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclohexyl]acetate is used as a precursor or intermediate in the development of new drugs. Its specific functional groups and structural features may contribute to the design and synthesis of novel therapeutic agents.
Used in Agrochemical Production:
2-[(1r,4r)-4-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclohexyl]acetate is also utilized in the agrochemical sector as a component in the production of pesticides, herbicides, or other agricultural chemicals. Its unique structure may offer advantages in the development of more effective and targeted agrochemicals.
Further research and evaluation of the properties of 2-[(1r,4r)-4-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclohexyl]acetate are necessary to fully explore and understand its potential applications in these fields.
Check Digit Verification of cas no
The CAS Registry Mumber 701232-69-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,1,2,3 and 2 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 701232-69:
(8*7)+(7*0)+(6*1)+(5*2)+(4*3)+(3*2)+(2*6)+(1*9)=111
111 % 10 = 1
So 701232-69-1 is a valid CAS Registry Number.
701232-69-1Relevant articles and documents
Discovery of 6-phenylpyrimido[4,5- B ][1,4]oxazines as potent and selective Acyl CoA: Diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents
Fox, Brian M.,Sugimoto, Kazuyuki,Iio, Kiyosei,Yoshida, Atsuhito,Zhang, Jian,Li, Kexue,Hao, Xiaolin,Labelle, Marc,Smith, Marie-Louise,Rubenstein, Steven M.,Ye, Guosen,McMinn, Dustin,Jackson, Simon,Choi, Rebekah,Shan, Bei,Ma, Ji,Miao, Shichang,Matsui, Takuya,Ogawa, Nobuya,Suzuki, Masahiro,Kobayashi, Akio,Ozeki, Hidekazu,Okuma, Chihiro,Ishii, Yukihito,Tomimoto, Daisuke,Furakawa, Noboru,Tanaka, Masahiro,Matsushita, Mutsuyoshi,Takahashi, Mitsuru,Inaba, Takashi,Sagawa, Shoichi,Kayser, Frank
, p. 3464 - 3483 (2014/05/20)
The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is described. The SAR of a moderately potent HTS hit was investigated resulting in the discovery of phenylcyclohexylacetic acid 1, which displayed good DGAT1 inhibitory activity, selectivity, and PK properties. During preclinical toxicity studies a metabolite of 1 was observed that was responsible for elevating the levels of liver enzymes ALT and AST. Subsequently, analogues were synthesized to preclude the formation of the toxic metabolite. This effort resulted in the discovery of spiroindane 42, which displayed significantly improved DGAT1 inhibition compared to 1. Spiroindane 42 was well tolerated in rodents in vivo, demonstrated efficacy in an oral triglyceride uptake study in mice, and had an acceptable safety profile in preclinical toxicity studies.
Proton exchange reactions in isotope chemistry (II) synthesis of stable isotope-labeled LCQ908
Jian, Zhigang,Ray, Tapan,Wu, Amy,Jones, Lawrence,Forseth, Ry
, p. 670 - 673 (2015/02/02)
The proton exchange reaction was applied to the preparation of stable isotope-labeled LCQ908. For this synthesis, a suitable intermediate with protons alpha to a carbonyl group was first subjected to the H-D exchange reaction; subsequent coupling of a car
