701298-37-5

Basic information

• Product Name: tert-butyl 4-[(2-hydroxyethyl)aMino]piperidine-1-carboxylate
• Synonyms: tert-butyl 4-[(2-hydroxyethyl)aMino]piperidine-1-carboxylate;4-((2-Hydroxyethyl)amino)piperidine-1-carboxylic acid tert-butyl ester;tert-Butyl 4-(2-azanylethylamino)piperidine-1-carboxylate
• CAS NO: 701298-37-5
• Molecular Formula: C₁₂H₂₄N₂O₃
• Molecular Weight: 244.33056
• Mol File: 701298-37-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 4-[(2-hydroxyethyl)aMino]piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-[(2-hydroxyethyl)aMino]piperidine-1-carboxylate(701298-37-5)
• EPA Substance Registry System: tert-butyl 4-[(2-hydroxyethyl)aMino]piperidine-1-carboxylate(701298-37-5)

Safety Data

• Hazardous Substances Data: 701298-37-5(Hazardous Substances Data)

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 141-43-5 ethanolamine 
• 41979-39-9 4-piperidone hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 925244-07-1 tert-butyl 4-{(2-hydroxyethyl)[3-(2-phenylethoxy)propanoyl]amino}piperidine-1-carboxylate 
• 1374856-78-6 4-(5-benzyloxycarbonyl-1,1-dioxo-1λ6-[1,2,5]thiadiazolidin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1374856-81-1 5-[1-(4-methyl-6-nitro-quinazolin-2-yl)-piperidin-4-yl]-1,1-dioxo-1λ6-[1,2,5]thiadiazolidine-2-carboxylic acid benzyl ester 
• 1374856-80-0 1,1-dioxo-5-piperidin-4-yl-1λ6-[1,2,5]thiadiazolidine-2-benzyl carboxylate trifluoroacetic acid salt 
• 1374856-16-2 (E)-N-(4-methyl-2-(4-(2-oxooxazolidin-3-yl)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide 
• 1374856-08-2 (E)-N-(4-methyl-2-(4-(3-oxomorpholino)piperidin-1-yl)quinazolin-6-yl)-3-(4 (trifluoromethoxy)phenyl)acrylamide 
• 710978-76-0 2-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-ethanol 
• 710978-91-9 4-[(4-fluoro-2-trifluoromethyl-benzyl)-(2-hydroxy-ethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

INHIBITORS OF SPHINGOSINE KINASE

The present invention relates to compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12,

Potent CCR4 antagonists: Synthesis, evaluation, and docking study of 2,4-diaminoquinazolines

A series of CC chemokine receptor-4 (CCR4) antagonists were examined in a previous report in an attempt to improve metabolic stability in human liver microsomes. In this study, the cycloheptylamine moiety of N-cycloheptyl-6,7-dimethoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine 1 was replaced with the p-chloroaniline moiety, and the resulting compound, N-(4-chlorophenyl)-6,7-dimethoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine (8c), retained its potency ([35S]GTPγS-binding inhibition and CCL22-induced chemotaxis in humans/mice). Based on the structure-activity relationships (SAR), a homology model was constructed for CCR4 to explain the binding mode of 8c. Overall, there was good agreement between the docking pose of the CCR4 homology model and the human [35S]GTPγS assay results. Administration of 8c in a murine model of acute dermatitis showed anti-inflammatory activity (oxazolone-induced contact hypersensitivity test).

UREA DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

The present invention provides a urea derivative or a salt thereof, which is useful as a therapeutic agent for thrombosis. The derivative is represented by Formula (I): [Chemical formula I] wherein Cy is an aromatic hydrocarbon group which may be substituted or an aromatic heterocyclic group which may be substituted; R1 is a hydrogen atom or a hydrocarbon group which may be substituted; V is -C(O)-, -S(O)-, or -S(O)2-; W is -N(R2)-, -O-, or a bond (wherein R2 is a hydrogen atom or a hydrocarbon group which may be substituted); X is alkylene which may be substituted; Y is -C(O)-, -S(O)-, or -S(O)2-; Z is a bond, a chain hydrocarbon group which may be substituted, or -N=; ring A is a non-aromatic nitrogen-containing heterocyclic ring which may be substituted; ring B is a nitrogen-containing heterocyclic ring which may be substituted; and [Chemical formula 2]------￣?,?------? are each independently a single bond or a double bond; provided that R1 may be bonded to R2 to form a non-aromatic nitrogen-containing heterocyclic ring and that R2 may be bonded to a substituent of X to form a non-aromatic nitrogen-containing heterocyclic ring which may be substituted.