70132-81-9

Upstream product

• 104-85-8 para-methylbenzonitrile 
• 100-68-5 methyl-phenyl-thioether 
• 5953-00-4 (2-chlorophenyl)(p-tolyl)methanone 

Downstream Products

• 144456-32-6 4-(1,2-benzisothiazole-3-yl)benzyl bromide 
• 144456-27-9 4-(1,2-benzisothiazol-3-yl)benzal bromide 
• 144456-28-0 4-(1,2-benzisothiazol-3-yl) benzotribromide 
• 78134-71-1 2,3-dihydro-3-ethoxy-5-tolyl-1,4-benzothiazepine 
• 70132-83-1 5-chloro-3-p-tolyl-benzo[d]isothiazole 
• 70132-84-2 5-nitro-3-p-tolyl-benzo[d]isothiazole 
• 144456-29-1 4-(1,2-benzisothiazol-3-yl) benzoic acid 
• 144456-31-5 4-(1,2-benzisothiazol-3-yl)benzamide 
• 144456-35-9 ethyl 4-(1,2-benzisothiazol-3-yl)phenylacetate 
• 144456-46-2 3-<4-(1,2-benzisothiazol-3-yl)phenyl>propionic acid 
• 144456-30-4 ethyl 4-(1,2-benzisothiazol-3-yl) benzoate 
• 144456-34-8 4-(1,2-benzisothiazol-3-yl)phenylacetic acid 
• 144456-36-0 4-(1,2-benzisothiazol-3-yl)phenylacetamide 
• 144456-33-7 4-(1,2-benzisothiazol-3-yl)phenylacetonitrile 

Relevant academic research and scientific papers

Preparation of Thioanisole Biscarbanion and C-H Lithiation/Annulation Reactions for the Access of Five-Membered Heterocycles

The synthesis, isolation, and X-ray structure of a thioanisole-based trilithium complex are reported. On the basis of the double-lithiation strategy, two novel synthetic methodologies have been developed under mild reaction conditions (room temperature): (1) reactions of lithiated thioanisoles with nitriles give benzoisothiazoles via a [3 + 2]-type of approach with two new bond formations and (2) formation of benzothiophenes from thioanisoles and amides through a [4 + 1] pattern forming 4 new chemical bonds.

Preparation method of benzisothiazole derivative

The invention discloses a preparation method of a benzisothiazole derivative. The method comprises the following steps that a benzyl disulfide (I), N,N,N',N'-tetramethylethylenediamine (II) and a C1-C10 lithium alkylide (III) normal hexane solution are sequentially added into a solvent, reaction, filtering and drying are performed to obtain di-lithium compound white powder, the di-lithium compound and a cyano compound (V) are subjected to a reaction under the room temperature, and the benzisothiazole derivative (VI) is obtained. The method has the advantages that operation is easy, reaction raw materials and reaction reagents are easy to obtain, product substituent groups have diversified types, and the yield is high.

Facile preparation of 3-substituted benzisothiazoles from o-mercaptoacylphenones

(Chemical Equetion Presentation) A synthesis of 3-substituted benzisothiazoles starting from readily available o-mercaptoacylphenones is presented. The key cyclization step features a mild S-nitrosation and its succeeding intramolecular aza-Wittig reactio

4-(1,2-benzisothiazol-3-yl)alkanoic and phenylalkanoic acids: Synthesis and anti-inflammatory, analgesic and antipyretic activities

Continuing their studies on benzisothiazolyl derivatives, Authors refer to the preparation and pharmacological properties of 4-(1,2-benzisothiazol-3-yl) alkanoic and phenyl alkanoic acids. All substances were tested for antiinflammatory, analgesic and ant

New Synthesis with Elemental Sulfur. - Preparation of 1,2-Benzisothiazoles and Some Secondary Reactions

The preparation of new 1,2-benzisothiazoles 2,3,5 and of thienoisothiazole 4 is described.The thioethers 8 have been obtained from 2 and 3 by ring opening with alcoholate and reaction with halomethyl compounds.On cyclisation, the thioethers 8 give the thionaphthenes 11.The ring systems of thionaphthenopyrimidines 10 and 12 have been prepared from 11.