70144-97-7

Upstream product

• 17922-76-8 N²-(benzyloxycarbonyl)-N¹-cyclohexylalaninamid 
• 33958-26-8 N-(tert-butoxycarbonyl)-(L)-alanine cyclohexylamide 
• 108-91-8 cyclohexylamine 

Downstream Products

• 159360-34-6 N²-<3--N-<3-<(tert-butoxy)carbonylamino>propyl>amino>propanoyl>-N'-cyclohexylalaninamid 
• 261354-86-3 (2S)-N¹-cyclohexyl-1,2-propanediamine 
• 1055974-96-3 1,1-dimethylethyl [(1S,2R)-3-{[(1S)-2-(cyclohexylamino)-1-methyl-2-oxoethyl]amino}-2-hydroxy-1-(phenylmethyl)propyl]carbamate 

Relevant academic research and scientific papers

Synthesis, characterization and docking studies of anti-HCV molecules

The present study reports the synthesis and characterization of novel molecules inhibiting the spread of hepatitis C. The molecules were designed as to block the NS3/4A protease enzyme on HCV RNA. The molecules were synthesized using usual peptide synthesis techniques. Compounds with purity more than 95% were characterized and docking studies were also performed. All the compounds were characterized using physico-chemical techniques such as determination of melting point by DSC and NMR, mass, IR spectral studies. The docking studies were also conducted to assess the activity of molecules for inhibition of hepatitis C virus.

Stereoselectivity and regioselectivity in nucleophilic ring opening in derivatives of 3-phenylisoxazolo[2,3-a]pyrimidine. Unpredicted dimerization and ring transformation. Syntheses of derivatives of pyrimidinylmethylamine, pyrimidinylmethylamino acid ami

The nucleophilic ring opening of the isoxazolone ring in 2-oxo-3-phenylisoxazolo[2,3-a]pyrimidine derivatives by optically active amino acid amides and ephedrine led to pyrimidinylmethylamino acid amides. Using amides of different L-amino acids and (-)-ep

Stereoselective syntheses of chiral (3S,9bS)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones

Chiral (3S,9bS)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones 11a-11f, 14b,14c and 17a,b were prepared in 78-93% yields with high stereoselectivities (d.e. >99%) by the intermolecular condensations of 2-formylbenzoic acids 10 or 13 or 2-acetylbenzoic acid 15 with chiral diamines 9a-9f and 9h. Compounds 9a-9f and 9h were readily prepared in three steps from optically active N-Boc-α-amino acids 5a-5d.

Synthesis of Polyamine Analoa of Spider Toxins

Within the last few years, polyamine toxins derived from various arthropods raised increasing interest due their interaction with glutamate receptors of insects and invertebrates.Compounds 51 and 52 were prepared together with 53-58 to study a new pathway