70147-27-2Relevant academic research and scientific papers
Anodic mediated synthesis and antifungal study of bis-1,3,4-oxadiazoles
Sharma,Saraswat,Singh,Siddiqui,Kehari,Singh
, p. 991 - 996 (2013/09/23)
A novel, facile and eco-compatible electrochemical synthesis of substituted bis-1,3,4-oxadlazoles have been carried out at platinum electrode via controlled potential electrocyclization of methylenediacylthiosemicarbazones in the presence of acetonitrile as non-aqueous solvent and LiClO4 as supporting electrolyte. The reaction products were characterized by spectroscopic methods and mechanism was deduced from cyclic voltammetry. The synthesized compounds were screened for their antifungal activity against Candida albicans, Alternaria solani, Aspergillus niger and results have been compared with the standard antifungal drug Griseofulvin. Excellent yields with high atom economy, shortest reaction time and easy work-up are attractive features in context to green chemistry.
