70150-36-6Relevant academic research and scientific papers
Integrative Theory/Experiment-Driven Exploration of a Multicomponent Reaction towards Imidazoline-2-(thi)ones
Kruithof, Art,Mulder, Jos R.,Ruiz,Janssen, Elwin,Mooijman,Ruijter, Eelco,Fonseca Guerra, Célia,Bickelhaupt, F. Matthias,Orru, Romano V. A.
, p. 104 - 112 (2018)
Predicting reactivity in multicomponent reactions (MCRs) is extremely difficult. These reactions proceed by multiple pathways and are inherently associated with a potentially large variation of reactants and functional groups. To date, theoretical chemist
Isothiocyanate Strategy for the Synthesis of Quaternary α-Amino Acids Bearing a Spirocyclic Ring System
Frankowski, Sebastian,Gajda, Tadeusz,Albrecht, ?ukasz
supporting information, p. 1822 - 1832 (2018/04/05)
This study demonstrates that isothiocyanates derived from α-substituted α-amino acids are useful building blocks in the heteroannulation reactions with electron-deficient olefins. The developed strategy proceeds in a cascade manner and involves Michael addition followed by a cyclization via nucleophilic addition. Target, spirocyclic heterocycles bearing either a quaternary α-amino acid moiety or α-aminophosphonate group have been efficiently synthesized in very high yield (up to 99%) and with excellent stereocontrol. The usefulness of heterocycles obtained has been demonstrated in selected transformations. (Figure presented.).
