7017-09-6

Basic information

• Product Name: ButanaMide, N-(4-chlorophenyl)-3-Methyl-
• Synonyms: ButanaMide, N-(4-chlorophenyl)-3-Methyl-
• CAS NO: 7017-09-6
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.68796
• Mol File: 7017-09-6.mol

Chemical Properties

• Melting Point: 117-118 °C
• Boiling Point: 359.2°Cat760mmHg
• Flash Point: 171°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 2.42E-05mmHg at 25°C
• Refractive Index: 1.556
• PKA: 14.25±0.70(Predicted)
• CAS DataBase Reference: ButanaMide, N-(4-chlorophenyl)-3-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: ButanaMide, N-(4-chlorophenyl)-3-Methyl-(7017-09-6)
• EPA Substance Registry System: ButanaMide, N-(4-chlorophenyl)-3-Methyl-(7017-09-6)

Safety Data

• Hazardous Substances Data: 7017-09-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H14ClNO/c1-8(2)7-11(14)13-10-5-3-9(12)4-6-10/h3-6,8H,7H2,1-2H3,(H,13,14)

Upstream product

• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 
• 104-12-1 p-chlorphenylisocyanate 
• 6622-16-8 benzyl (4-chlorophenyl)carbamate 
• 940-36-3 (4-chloro-phenyl)-carbamic acid methyl ester 
• 100-99-2 triisobutylaluminum 

Relevant articles and documents

Practical one-pot amidation of N -Alloc-, N -Boc-, and N -Cbz protected amines under mild conditions

A facile one-pot synthesis of amides from N-Alloc-, N-Boc-, and N-Cbz-protected amines has been described. The reactions involve the use of isocyanate intermediates, which are generated in situ in the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, to react with Grignard reagents to produce the corresponding amides. Using this reaction protocol, a variety of N-Alloc-, N-Boc-, and N-Cbz-protected aliphatic amines and aryl amines were efficiently converted to amides with high yields. This method is highly effective for the synthesis of amides and offers a promising approach for facile amidation.

First Carbamates Conversion to Amides by Simple Alkyl Group Transfer from Trialkylalanes

(Equation presented) N-Monosubstituted carbamates are cleanly converted to amides under treatment with trialkylaluminum. This reaction involves an aluminum-assisted internal delivery of alkyl groups. It can be applied to new and mild protecting group strategies for alcohols.