701914-09-2

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 2065-66-9 methyl-triphenylphosphonium iodide 

Downstream Products

• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 701913-77-1 (R)-2-phenyl-cyclopropanecarboxylic acid [1-(4-fluoro-3-morpholin-4-yl-phenyl)-2-hydroxy-ethyl]-amide 
• 701914-11-6 (R)-4-[1-(fluoro-3-morpholin-4-yl-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester 
• 701914-10-5 4-(2-fluoro-5-vinyl-phenyl)-morpholine 

Relevant academic research and scientific papers

Copper-Catalyzed Oxidative Difunctionalization of Terminal Unactivated Alkenes

The copper(II)-promoted free-radical oxidative difunctionalization of terminal alkenes to access ketoazides by utilizing molecular oxygen has been reported. A series of styrene derivatives have been evaluated and were found to be compatible to give the desired difunctionalized products in moderate to good yields. The role of molecular oxygen both as an oxidant and oxygen atom source in this catalytic transformation has been unquestionably demonstrated by 18O-labeling studies and a radical mechanistic pathway involving the oxidative formation of azidyl radicals is also designed. This environment-friendly catalytic oxidative protocol can transform aldehyde to nitrile.

Arylcyclopropylcarboxylic amides as potassium channel openers

The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I wherein R, R1, R2, R3, R4, R5, R6 and R7 are as defined